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Projects. Life and Earth Sciences

Differential Interactome Depending on WIP Oncogenic or Tumor-Suppressing Activity

Lead Researcher: Inés María Antón Gutiérrez
Research Centre: CIBERNED/CNB-CSIC. Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas-Centro Nacional de Biotecnología. Madrid.

Abstract:

Inés María Antón GutiérrezCancer is a genetically and clinically heterogeneous disease, and therefore the search for effective combinational therapies is linked to cancer study through extensive "Omic" approaches (genomics, proteomics, lipidomics, etc.). In this sense, the interactome aims to hierarchically order the modified and unmodified cellular signals in pathological situations.

WIP (WASP Interacting Protein) is part of a regulatory complex for actin polymerization, an essential process for cell migration and tumor invasion, and is expressed differentially in tumor initiating cells (TIC). The most recent tumor therapies are directed towards the elimination of these cells as they are the most resistant to chemotherapy. Our preliminary results indicate that WIP exhibits opposite dual activity in its contribution to oncogenic development, acting as tumor suppressor in large cell anaplastic lymphomas (ALCL) and as an oncogene in TICs of solid tumors, both in breast cancer and in glioblastomas. Using qualitative and quantitative proteomics approaches, this project proposes to identify how the WIP interactome changes between tumors of hematopoietic and non-hematopoietic origin, to functionally validate the identified proteins, and to complete it with a chemical and genetic library screening to identify potential therapeutic targets that facilitate the search of specific tumor therapies in each system.

We are confident that the results derived from this project will contribute to identify compounds and/or genetic tools to reach the challenge of improving the quality of life of cancer patients and reducing tumor-associated deaths.


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