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Projects. Life and Earth Sciences

Study of the regulation of protein PSTPIP1 via tyrosine phosphorylation and its contribution to the aetiology of the PAPA autoinflammatory disease

Lead Researcher:
Andrés Alonso García   

Research Centre:
Instituto de Biología y Genética Molecular. CSIC. Valladolid.

Synopsis:
Andrés AlonsoPSTPIP1 is involved in activation of the inflammasome, which generates the active form of IL 1beta. The mutations A230T and E250Q in PSTPIP1 cause the autoinflammatory disease known as PAPA. These mutations affect a region of this protein that interacts with the PTPPEST tyrosine phosphatase, blocking its interaction, which leads to increased phosphorylation of PSTPIP1. At present it is unknown what role tyrosine phosphorylation plays in regulating PSTPIP1 and what importance it can have for the function of this protein in inflammatory response. It is also unknown which stimuli and signalling pathways are involved in the phosphorylation of PSTPIP1. This project proposes to study the physiological function of PSTPIP1 in the inflammatory response and determine the molecular mechanisms by which PSTPIP1 intervenes in the pathogenesis of PAPA autoinflammatory disease.


SCIENTIFIC PRODUCTION

 
1 article published in Journals
1 paper at national conferences

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Andrés Alonso García A native of Salamanca, where he studied biology, he completed his Ph.D. at the University of Valladolid, investigating the induction of gene expression in macrophages by inflammatory stimuli. In 1999 he moved to San Diego, California, to continue his post-doctoral training, performing a more in-depth study of signalling in the immune system, in this case investigating the role of different tyrosine phosphatases in T cell antigen signalling. Returning to Valladolid in 2004, he joined the Molecular Biology and Genetics Institute (IBGM) in Valladolid, where he is currently a senior scientist for the CSIC. His work is focused on the study of the role of tyrosine phosphatases in immune system cells and the alterations of these proteins that can lead to the emergence of various diseases.


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