Jump to resource

Projects. Life and Earth Sciences

Structural approach to the molecular basis of two rare kidney diseases 

Lead Researcher:
Óscar Llorca Blanco 

Research Centre: 
Centro de Investigación: Centro de Investigaciones Biológicas. CSIC. Madrid.

Synopsis:
Óscar LlorcaThe complement system plays a critical role in innate immunity and its deregulation leads to serious rare diseases due to a lack of treatments, such as dense deposit disease (DDD) or atypical haemolytic uraemic syndrome (aHUS). This project aims to combine genetic, biochemical and structural studies to resolve the mechanisms regulating complement system activation. Resolved structures will allow the identification of critical regions in the assembly and regulation processes, which will help explain the mutations found in patients as well as facilitate the design of compounds to prevent or reduce tissue damage caused by uncontrolled activation of the complement system. 

SCIENTIFIC PRODUCTION   

4 articles published in Journals
1 paper at national conferences 
3 papers at international conferences  
_______________________________________

Óscar Llorca Blanco 

Date of Birth: 10th January 1968 
Place of Birth: TUDELA (NAVARRE)

EDUCATION

Degree in Science (Biology). Average mark: 3.8 out of 4
UNIVERSITY OF NAVARRE
JULY 1992


THIRD NATIONAL AWARD FOR COMPLETION OF STUDIED


Ph.D. SCIENCE (MOLECULAR BIOLOGY). Passed cum laude.
AUTONOMOUS UNIVERSITY OF MADRID
4th JULY 1996

PREVIOUS SCIENTIFIC OR PROFESSIONAL ACTIVITIES

May 2007 - 2008 Research Scientist at CSIC, CIB, Madrid

Jun 2002 - April 2007 Senior Scientist at CSIC, CIB, Madrid

Dec 2000 - May 2002 INSTITUTE OF CANCER RESEARCH, London, UK
"MARIE CURIE" POSTDOCTORAL FELLOW OF THE EUROPEAN COMMISSION

Jul 1996 - Nov 2000 National Centre for Biotechnology - CNB-CSIC
POSTDOCTORAL FELLOW.

Oct 1992 - Jul 1996 National Centre for Biotechnology - CNB-CSIC
PREDOCTORAL FELLOW.

Jul 1992 - Oct 1992 Molecular Biology Centre - CNB-CSIC. FELLOWSHIP OF INTRODUCTION TO RESEARCH.

Oct 1989 - Jun 1992 University of Navarre. FELLOWSHIP OF COLLABORATION.

PRIZES, AWARDS AND OTHER ACHIEVEMENTS

- Francisco Cobos Foundation Award, 2007 edition, in recognition of his research career in biomedicine.
- Evaluator of projects for the ANEP and the Ministry of Science and Innovation
- Expert on Evaluation Panel for the Call for Starting Grants by the ERC (European Research Council). Panel: Life Sciences.


MAJOR SCIENTIFIC CONTRIBUTIONS


Oscar Llorca has published around 60 scientific articles in renowned journals, including Nature, Molecular Cell, PNAS USA and EMBO Journal.


These studies have provided information on the three-dimensional structure and functioning mechanisms of various macromolecular complexes essential for cell survival and relevance in human health, such as damage repair systems in DNA, or the complement system in innate immunity.


*All intellectual property rights belong to the author. Reproduction of all or part of the work without permission from the author is prohibited.

© RAMÓN ARECES FOUNDATION. All rights reserved. 


Síguenos en

  • Twitter
  • Facebook
  • Flickr
  • Youtube
  • Slideshare

© 2007 Fundación Ramón Areces All rights reserved.

c/ Vitruvio, 5. 28006 Madrid (España) | Telephone: 91 515 89 82 | C.I.F.: G-28459311