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Projects. Life and Earth Sciences

Contributions of aquaporins and transduction proteins in the treatment of achondroplasia

Lead Researcher:
Jesús Pintor Just

Research Centre: 
Escuela Universitaria de Óptica. Universidad Complutense. Madrid. (Spain).

Synopsis:
Jesús PintorThe project concerns the role of aquaporins and water movement in achondroplastic cells (chondrocytes). The objectives described in the original report are: 1. Study of the presence and distribution of aquaporins in normal and achondroplastic chondrocytes, studying their distribution as the chondrocyte matures. 2. Silencing of aquaporins to understand their physiological relevance in the normal and achondroplastic chondrocyte. 3. The effect that the normal and achondroplastic FGFR3 receptor has on traffic of aquaporins to the plasma membrane and on the expression of these proteins. 4. Effects of Ap4A and PPADS on aquaporins. 5. Use of the Tat transcription protein to block characteristic overactivation of FGFR3 receptors in achondroplasia and its effect on aquaporins.

SCIENTIFIC PRODUCTION   

2 articles published in Journals
2 papers at national conferences 
2 papers at international conferences 
________________________________________

Jesús Pintor Just
In 1989, he graduated with a degree in Biology from the Complutense University of Madrid and obtained a Ph.D. from the same university in 1993. He has spent several sojourns at foreign institutions such as Johann Wolfgang Goethe University in Frankfurt, Germany (1990), the Bogomoletz Institute in Kiev, Ukraine (1992) and University College London, in the United Kingdom (1994) (under a scholarship awarded by the Ramón Areces Foundation). He is currently a senior lecturer at the Complutense University of Madrid in the Department of Biochemistry and Molecular Biology IV at the College of Optics and has full professor accreditation. Between 1990 and 1993 his research focused on the study of the presence of diadenosine polyphosphates in neurosecretory cells and nerve endings as well as a description of their receptors.


Currently his research is focused on the following lines:
a. Intraocular pressure - glaucoma (since 1998).
b. New substances for the treatment of dry eye (since 2000).
c. Effect of nucleotides and melatonin on corneal re-epithelialisation (since 2002).
d. Treatment of achondroplasia - dwarfism, (since 2003).


He has directed three doctoral theses and is currently directing three others. Dr. Pintor has published 113 articles in scientific journals indexed in the Science Citation Index (SCI), has participated in 47 funded research projects and contracts and is the inventor of 13 patents. 
Other Merits
- Member of the Royal Academy of Pharmacy since 2005.
- Deputy director of Research at the College of Optics since 2006.
- "Honorary Young Lecturer" at the 10th Congress of the European Society for Neurochemistry (ESN), Jerusalem (Israel) (1994).
- Winner of 2nd Madrid Region Competition for Spin-Off Ideas organised by Investigación MadrI+D in the area of biotechnology for the creation of a company. Title of the Project: "Assessment of drug research: at the service of other companies" (2004).
- Winner of Runner-up Prize for Best Patent at the 4th Madrid Region Patent Competition. Title of the Patent: "Use of nucleotides and dinucleotides in the treatment of ocular surface infections" (2007). 
 
*All intellectual property rights belong to the author. Reproduction of all or part of the work without permission from the author is prohibited.

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