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Projects. Life and Earth Sciences

Effect of the oleic acid neurotrophic factor in an animal model of Down syndrome. Implications for central nervous system development

Lead Researcher:
Ana Velasco Criado 

Research Centre:  
Instituto de Neurociencias de Castilla y León. Universidad de Salamanca. (Spain).

Synopsis:
Ana VelascoThe objectives achieved so far are: Cell lines derived from mice have been obtained, one derived from a normal mouse, CNh, and the other derived from a mouse with trisomy, CTb. These lines behave differently in the presence of oleic acid. When the CNh line is incubated in the presence of oleic acid, it produces a cell clustering characteristic of cell differentiation. In addition, we have analysed the expression of the enzyme involved in the formation of the acetylcholine neurotransmitter, choline acetyltransferase (ChAT). Oleic acid increases the expression of this enzyme in CNh cells. However, neither of these effects, cell clustering nor increased ChAT expression, is reproducible in the CTb line. These results strengthen the effect of oleic acid during brain development and help to further research on the mechanisms involved in brain development in Down syndrome.


SCIENTIFIC PRODUCTION

1 article published in Journals
2 papers at national conferences
  
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Ana Velasco Criado 
Degree in Pharmacy (U. Salamanca, 1998). Ph.D. in Pharmacy, Special Prize (2003). Associate Lecturer (3 hours), University of Salamanca (2003-2004). Assistant Ph.D. Lecturer, University of Salamanca (since 2007).

Biochemistry teaching in the Medicine and Biochemistry degree courses. Scholarship from the Ministry of Health and Consumer Affairs (BEFI-FIS) (1999-2003). Postdoctoral scholarship from the Ministry of Education and Science (2005-2007). Short predoctoral sojourn at the laboratory of Dr. J.M. Ntambi in the Department of Biochemistry at the University of Wisconsin, USA. Postdoctoral sojourn at the laboratory of Dr. M. Goedert at the Medical Research Council, Cambridge, United Kingdom.

Predoctoral scientific publications: J. Neurochem., 2000, 74, 1249-1256; J. Neurochem., 2001, 78, 890-898; J. Neurochem., 2001, 79, 606-616. J. Biol. Chem., 2002, Feb., 277(6), 4240-4246; Brain Res., 2003, 977, 103-111; J. Neurochem., 2004, 88, 1041-1051. Postdoctoral scientific publications: J. Neurochem., 2008, 105, 1428-1432; FEBS lett., 2008, 582, 901-906; J. Neurochem., 2008, 106, 1149-1159; J. Neurochem., 2009, 111, 49-60.

Member of the Spanish Society of Biochemistry and Molecular Biology.


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