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Projects. Life and Matter Sciences

Epigenetic control of cellular differentiation and pluripotency by the BRAF35 and iBRAF proteins

Lead Researcher:
José Carlos Reyes Rosa

Research Centre:
Centro Andaluz de Biología Molecular y Medicina Regenerativa. CSIC. Sevilla. (Spain).

José Carlos ReyesEpigenetic control mechanisms for gene expression are paramount in the differentiation and maintenance of the characteristics of stem cells. The REST transcription factor is essential for keeping the expression of neuronal genes in non-neuronal tissues repressed through various epigenetic mechanisms, as well as for the maintenance of pluripotency and self-renewal in stem cells. The BHC multiprotein complex is a REST co repressor through the action of histone deacetylases and histone H3 demethylase at lysine 4. This project investigates how the activity of the BHC complex is regulated by the interaction of two homologous proteins called BRAF35 and iBRAF and what are the consequences of this regulation in neuronal differentiation and pluripotency.


1 article published in Journals
1 paper at national conferences
6 papers at international conferences  

José Carlos Reyes Rosa
Ph.D. in Biological Science at the University of Seville. He completed his doctoral thesis at the Institute of Plant Biochemistry and Photosynthesis (CSIC) between 1990 and 1994, where he conducted studies on gene expression in cyanobacteria. He later did a postdoctoral sojourn at the Institute Pasteur in Paris where he began his studies of chromatin and epigenetic remodelling. After a brief stint as a visiting professor at the National Institute of Health in Bethesda (USA), in 2000 he obtained a position as a Senior Scientist at CSIC. In 2002, he received the Young Researcher Award from the Seville Academy of Sciences. Between 2002 and 2006, he was Deputy Director of the Institute of Plant Biochemistry and Photosynthesis in Seville. He currently heads a research group at the Andalusian Centre for Molecular Biology and Regenerative Medicine (CABIMER). He has published 52 articles on different topics which are always related to gene expression both in bacteria and in plants and animals. Currently his group is investigating the mechanisms of regulation for chromatin remodelling complexes in animal cells, which are the basis of essential processes such as development, cell differentiation and cancer.

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