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Projects. Life and Earth Sciences

Epigenetic regulation of the maintenance of genomic stability during mitotic and meiotic cell cycle

Lead Researcher:
Pedro Antonio San Segundo Nieto 

Research Centre:
Instituto de Microbiología Bioquímica. CSIC-Universidad de Salamanca. (Spain).

Synopsis: 
Pedro Antonio San SegundoThe factors regulating the dynamics of chromatin play a key role in the detection, signalling and repair of lesions in the genome and, therefore, in maintaining genomic integrity. This project studies the epigenetic molecular mechanisms involved in the regulation and monitoring of meiotic recombination and the response to DNA damage in the mitotic cell cycle, with special emphasis on the role of specific histone modifications and chromatin remodelling complexes. To this end, the Saccharomyces cerevisiae yeast is used as a study model. Given the evolutionary conservation that exists in the cell cycle checkpoints, yeast studies are relevant to the advancement of knowledge of the mechanisms that contribute to the maintenance of genetic integrity in higher eukaryotes.

 

SCIENTIFIC PRODUCTION


3 articles published in Journals 
5 papers at international conferences   
________________________________________

Pedro Antonio San Segundo Nieto
Education.

1988. Degree in Biology (Univ. of Salamanca) with a Special Degree Prize.
1994. Ph.D. in Biology (Microbiology and Genetics Dept. Univ. of Salamanca) with a Special Doctorate Prize.
1995-2000. Postdoctoral sojourn at Yale University / Howard Hughes Medical Institute. New Haven, USA.
2001. Reinstatement Contract with the Ministry of Education and Science.
2002-2005. Ramón y Cajal researcher. Institute of Molecular and Cellular Biology of Cancer. Salamanca.
2005-Present. Senior Scientist CSIC. Institute of Biochemical Microbiology. Salamanca.

Summary of Scientific Contributions.

Principal Investigator on 10 national and regional research projects.
16 research articles in international journals.
15 papers at national conferences and 28 papers at international conferences. Guest speaker at 6 conferences or seminars.
2 doctoral thesis supervised and 3 currently in development.

Other Merits

Regular reviewer of manuscripts submitted for publication to various international journals in the areas of Genetics and Cell Biology.
Member of the Nature Reader Panel (Nature Publishing Group) by invitation. 2009 and 2010.
Member of the Spanish Society of Biochemistry and Molecular Biology. Involved in teaching several Ph.D. and/or Masters courses at the Universities of Salamanca, Barcelona and Seville.


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