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Projects. Life and Earth Sciences

Phototherapy: resonant gold nanoparticles in the near infrared for photothermal ablation of tumour cells and for activation of therapeutic genes

Lead Researcher:
Manuel Arruebo Gordo 

Research Centre: 
Institute of Nanoscience of Aragón. University of Zaragoza.

Synopsis: 
Manuel ArrueboThe development of this research project involves the generation of gold nanoparticles as biomaterials applicable to anti-tumour therapy by photoinduced hyperthermia using a laser in the near infrared (NIR) range in combination with a gene therapy approach to refine the procedure, avoiding adjacent healthy tissue destruction, and strengthening the destruction of the tumour area affected. Specific objectives include: i) to synthesise and characterise properties of nanoparticles with surface plasmon resonance; ii) to demonstrate their physical stability in physiological media and their stability after lyophilisation in order to achieve a pharmacologically stable preparation; iii) to determine the subcytotoxic doses of the nanoparticles to be used in subsequent phototherapy experiments and gene transfer; iv) to implement NIR laser-induced experimental phototherapy equipment; v) to assess the ability of synthesised nanoparticles to raise the temperature of the cells through photoinduced hyperthermia using an NIR laser; vi) to explore the ability of nanoparticles to activate a telltale gene controlled by a human hsp70 gene promoter after application of an NIR laser and produce a localised rise in temperature, and finally vii) to disseminate the results with the aim of assessing the quality of research, expanding understanding, interacting with other groups in the area and continuing with the investigation which has been initiated.

SCIENTIFIC PRODUCTION

1 article published in Journals
3 papers at international conferences  
________________________________________

Manuel Arruebo Gordo
Doctor in Chemistry from the Department of Chemical Engineering and TMA at the University of Zaragoza. Ramón y Cajal researcher at the University of Zaragoza. Postdoctoral researcher at the University of Colorado at Boulder, USA and Visiting Scholar at the University of Science and Technology in Hong Kong, China and at Harvard /MIT, Cambridge, Massachusetts, USA.
Author of 27 popular science articles and 3 patents. His six most important articles are:

1) Reported nanosafety practices in research laboratories worldwide. Nature Nanotechnology 5 (2010) 1-4.

2) Drug delivery from internally implanted biomedical devices used in traumatology and in orthopaedic surgery. Expert Opinion on Drug Delivery 7 (2010) 1-14.

3) Assessing Methods for Blood Cell Cytotoxic Responses to Inorganic Nanoparticles and Nanoparticle Aggregates. Small 4 (2008) 2025-2034.

4) Magnetic nanoparticles for drug delivery applications. Nano Today 2(2007) 22-32.

5) Antibody-functionalised hybrid superparamagnetic nanoparticles. Advanced Functional Materials 17 (2007) 1473-1479.

6) Development of magnetic nanostructured silica-based materials as possible vectors for drug-delivery applications. Chemistry of Materials 18 (2006) 1911-1919.

Principal Investigator in 3 scientific projects and he has participated in 15 as a research assistant or as a Ph.D. student.

Guest speaker at two international conferences (the 11th Joint MMM-Intermag Conference, 18th-22nd January 2010 in Washington DC, USA and the Asia-Pacific Chemical and Biological Microfluidics Conference, 24th-26th June 2009 in Hong Kong China). Awarded two Sectoral Prizes: 3M Innovation Foundation.

Awarded in the 8th edition (2006). Health Area and E. Pérez Castro Prize 2007 for the article: "Research study on renal targeted chemotherapy with magnetic harpoons and intravenous administration of ferro-carbon nanoparticles".

*All intellectual property rights belong to the author. Reproduction of all or part of the work without permission from the author is prohibited.
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