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Projects. Life and Matter Sciences

Application of biomaterials with angiogenic, antioxidant and regenerative purposes in the central nervous system

Lead Researcher: 
José Miguel Soria López 

Research Centre:
Faculty of Health Sciences. CEU-Cardenal Herrera University. Valencia. (Spain).
José Miguel SoriaCurrently, the vast majority of neurodegenerative disorders that affect brain structures lack an effective clinical strategy for their treatment. Regenerative medicine aims in these cases to achieve an approach based on cell transplantation. However, it needs to have a cell support structure that allows positioning and functional behaviour. It is therefore of the utmost importance to identify synthetic, biodegradable and stable materials, compatible with brain tissue, and capable of promoting angiogenesis processes which ensure the formation of blood vessels inside for adequate cell survival inside the scaffolding. The project goals are the identification of materials on which neural cells are viable and functional. For the development of this study, in vitro studies will be developed to determine the viability, proliferation and differentiation of vascular endothelial cells. In parallel, the viability the use of biomaterials will be studied in vivo along with the characterisation of their functional integration in an experimental mouse model with local brain damage.


1 article published in Journals
2 papers at national conferences 
2 papers at international conferences  

José Miguel Soria López
Degree in Biology from the University of Murcia (1990). He completed his doctoral thesis (2000) entitled "Issues in the development of the cerebral cortex of mice" at the Institute of Neurosciences, Miguel Hernández University, in collaboration with University College London, and Biozemtrum in Switzerland. The development of his doctoral thesis yielded scientific publications in international conferences and journals in the field of neuroscience such as Cerebral Cortex, European Journal of Neuroscience and Journal of Comparative Neurology.

After completing his doctoral studies, he completed a brief postdoctoral sojourn at the Faculty of Medicine, Autonomous University of Madrid, where he completed his studies on functional aspects in mammalian cortical development.

Later, as a result of a Marie Curie scholarship he joined the Cell Biology laboratory at the DIBITT-San Raffaele Hospital Research Institute in Milan (Italy) where he spent 3 years. During this period, José Miguel Soria increased his knowledge of Cellular and Molecular Biology in aspects relating to Neurogenesis and the cerebral cortex. After this period of training as a researcher, José Miguel Soria joined the Laboratory of Developmental Biology at the Dulbecco-Telethon Institute in Milan (Italy) specialising in Biomedical Technology, where he remained for two years, obtaining results that were published in prestigious international journals such as Development and Neuroscience Journal. The results and his training so far allowed José Miguel Soria to return to Spain as an FIS researcher at the King Charles III Institute to lead the Cellular Therapy Laboratory at the General University Hospital in Valencia, where he remained until 2008. During this period, José Miguel was Principal Investigator on national-level research projects whose main objective was the use of biomaterials for neuro-regenerative purposes in the cerebral cortex. The results of these projects were the subject of international publications in the field of Cell Therapy. This research facet has always been combined with teaching at the Faculty of Biology and the Faculty of Medicine at the University of Valencia. In 2008, José Miguel Soria joined the Department of Physiology and Pharmacology at the Cardinal Herrera CEU University in Moncada (Valencia) as a lecturer, where he continued to develop his research projects in the field of cell therapy using funding from the King Charles III Institute (CIBER for Neurodegenerative Diseases) and the Valencian Regional Government's Health Department. Currently, José Miguel Soria is the Director of the Department of Nursing at the Cardinal Herrera CEU University in Valencia and is part of a multidisciplinary team in collaboration with the University of Valencia and the Polytechnic University of Valencia. The latest research project funded by the Ramon Areces Foundation is proposed as a new challenge in the development of new neuro-regenerative strategies in the cerebral cortex.

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