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Projects. Life and Earth Sciences

High resolution profiles of acetylation and methylation of histones in the epigenome of Arabidopsis thaliana: functional connection with the biological clock

Lead Researcher:
Paloma Más Martínez 

Research Centre:
Consorcio CSIC-IRTA-UAB. Centro de Investigación en Agrigenómica (CRAG). Barcelona. (Spain).

Synopsis:
Paloma MásThe project is interested in understanding the regulatory and functional mechanisms of the circadian clock using Arabidopsis thaliana plants as an experimental model. This project aims firstly to perform global studies to examine histone modifications in the epigenome of Arabidopsis, characterising the clock function and the environmental factors in this regulation. The aim is also to identify patterns of histone modification directly regulated by CCA1 and other transcription factors essential to the operation of the clock. To that end, samples of wild plants with mutations and overexpression in each component will be used and there will be an examination in vivo and at a genomic level of the acetylation and methylation of histones using the chromatin immunoprecipitation technique followed by mass sequencing (ChIP-Seq). This is intended to obtain high resolution combinatorial profiles of histone methylation and acetylation in the epigenome of Arabidopsis thaliana and define the role of different components of the clock and various environmental factors in the epigenetic regulation of genes controlled by the clock.

SCIENTIFIC PRODUCTION  

3 articles published in Journals
3 papers at national conferences
6 papers at international conferences  
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Paloma Más Martínez 
She did her Ph.D. (1993-1997) under the supervision of Dr. Vicente Pallás (CEBAS-CSIC, Murcia, Spain) and the studies focused primarily on molecular and cellular characterisation of cherry leaf roll virus (CLRV). During her first postdoctoral sojourn (1997-1999) in the laboratory of Dr. Roger Beachy at the prestigious Scripps Research Institute (California, USA), her studies were focused on the essential mechanisms regulating the viral infective cycle. The results of her predoctoral and postdoctoral research resulted in several important publications in the field of virology. In a second postdoctoral sojourn (2000-2003) in the laboratory of Dr. Steve Kay (ICND, California, USA), her research focused on the study of the biological clock and the importance of circadian rhythms in the control of the physiology and metabolism of plants. The work completed there was published in prestigious high-impact journals such as Nature and Science. The relevance of this work is reflected in many invitations to write reviews, book chapters and popular articles as well as her invitations to Conferences as a guest speaker. This experience also led to her being awarded highly competitive and prestigious prizes, such as the EURYI and EMBO YIP prize. At the national level, since entering the Spanish science system in 2004, Dr. Paloma Más was recently promoted top of her year to the rank of Research Scientist at the CSIC in the Department of Biology and Biomedicine.


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