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  1. Biotechnological basis for the development of functional foods in the field of intestinal maturation, inflammatory bowel disease and irritable bowel s

Biotechnological basis for the development of functional foods in the field of intestinal maturation, inflammatory bowel disease and irritable bowel s

Biotechnological basis for the development of functional foods in the field of intestinal maturation, inflammatory bowel disease and irritable bowel syndrome 

Lead Researcher:
Fermín Sánchez de Medina López-Huertas

Research Centre: 
Facultad de Farmacia. Universidad de Granada. (Spain).

Synopsis:

Fermín Sánchez de MedinaThe project aims to establish a solid foundation for the application of functional foods to various intestinal diseases. The project focuses on two intestinal diseases: inflammatory bowel disease and irritable bowel syndrome, as well as intestinal maturation in newborns. Specifically: (1) The intestinal anti-inflammatory activity of the routine glycomacropeptide and 3 non-absorbable glucides will be assessed in the lymphocyte transfer model in mice. This is important because the models used to date are not strictly chronic and require validation in a lymphocyte-mediated model rather than an innate immunity model. (2) The potential therapeutic effect of these compounds will be studied in an irritable bowel syndrome model. Although its pathology is complex and poorly understood, it is believed that there is a certain underlying inflammatory component, validating the working hypothesis that there may be a therapeutic effect. (3) The study will complement the effects on intestinal maturation of those compounds for which data are still lacking in this regard. In all cases functional and biochemical analysis will be performed as well as a genomic study using post-genomic microarray and validation by quantitative PCR. .

SCIENTIFIC PRODUCTION 

3 articles published in Journals
11 papers at national conferences
6 papers at international conferences  
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Fermín Sánchez de Medina López-Huertas 
• Degree in Pharmacy from the University of Granada (1991), with a Special Degree Prize from the UGR.
• Ph.D. from the same university (1996), under the supervision of Dr. Zarzuelo, Dr. Gálvez and Dr. Jiménez, with a Special Doctorate Prize. Part of the thesis was conducted at the University of California at San Diego in the laboratory of Dr. Kim Barrett.
• Postdoctoral training at Johns Hopkins University (Baltimore), 1996-98, in the laboratory of Dr. Mark Donowitz.
• Senior Lecturer in the Dept. of Pharmacology at the University of Granada since 2002, following the award of a reinstatement contract and hiring as an "LRU assistant".
• Director of the Office of International Projects at the University of Granada (2008-present).
• Member of the Networked Biomedical Research Centre for Liver and Digestive Diseases (CIBEREHD).
• Award from "Official Association of Pharmacists of the Province of Granada" and the Ibero-American Academy of Pharmacy (2004).
• Principal Investigator on two projects within the national plan, as well as two CENIT projects and three contracts with companies.
• Author of 40 articles, mostly located in the top quartile of their category in terms of impact factor.
• Reviewer for numerous scientific publications and national agencies, member of the editorial board of the journal Pharmacological Research  

Research interests: Pathophysiology and pharmacology of inflammatory bowel disease, functional foods, obesity.

*All intellectual property rights belong to the author. Reproduction of all or part of the work without permission from the author is prohibited.
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