She undertook her doctoral thesis under the supervision of Dr. Sanchez-Madrid in La Princesa Hospital, opening up a line of research into multimolecular complexes of bound tetraspanins. Following two visits to the laboratories of Dr. Nelson (Stanford) and Dr. Trendelemburg (Heidelberg), she combined development of the Unidad de Videmicroscopía del Hospital de La Princesa with her research work in a multidepartment work published by the The New Engl J Med, which gave rise to a patent.

As a Miguel Servet researcher, firstly in the Hospital de La Princesa and subsequently in the CNIC, she commenced her current lines of research: 1) tetraspanin intracellular connections, 2) the functional association of tetraspanins with proteases. In 2009 she joined the Instituto de Investigación Sanitaria Princesa as head of the Grupo Emergente, and she is now director of the Unidades Técnicas de Apoyo. In 2014 she gained a Ramón y Cajal contract in the UAM.

Dr. Yáñez-Mó is a founder member and secretary of the Grupo Español de Investigación e Innovación en Vesículas Extracelulares (GEIVEX) and is a member of the Management Committee of the BM1202-European COST Network on Microvesicles and Exosomes in Health and Disease.

She has now published 59 articles and has an h index of 32.