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Legionella and Legionnaires' disease: virulence, clinical aspects and control

Life and Matter Sciences Session February 14th, 2019 Madrid

General information

Venue: Fundación Ramón Areces, C/ Vitruvio, 5. 28006. Madrid

Simultaneous interpretation. Free assistance. Limited capacity

Coordinator/s:

Manuel SegoviaHospital Clínico Universitario Virgen de la Arrixaca. Universidad de Murcia, España 

  • Description
  • Programme

Legionella is one of the main causative agents of severe atypical pneumonias, particularly among people with impaired immune systems. Present in soil and natural aquatic environments, legionellae have also found an ecological niche in anthropogenic aquatic environments such as potable water networks, hot and cold sanitary water systems, industrial facilities and wastewater treatment plants. Legionnaires´diseases outbreaks occur throughout the world affecting public health with the consequent impact on different economic activities such as tourism and the industrial sector.

During more than 40 years, since the first legionnaire`s disease outbreak, the importance of appropriate risk assessment on water systems has been recognized to rapidly apply the best control measures and adopt different disinfection procedures, being aware that each facility has its own idiosyncrasy. In this sense, knowledge on ecological niches of Legionella has been expanded, and the implementation of new sequencing technologies and metagenomic to monitor microbial population in water systems appear to be quite promising for a better understanding of behaviors devised by this bacterium to survive in the environment.

Regarding diagnostic, the qPCR has appeared as alternative method to the gold standard based on culture isolation and its usefulness have been demonstrated in clinical and environmental samples. Nevertheless, some remaining limitations, oblige all the scientific community to do a huge effort to develop new fast and accurate diagnostic technologies that permit the rapid and easy detection of Legionella. New molecular technologies help to clarify the molecular basis of pathogenesis and evolution of this bacterium.

Thursday, 14

9:30 h.

Welcome and presentation

Emilio Bouza   
Consejo Científico de la Fundación Ramón Areces. 
Hospital Universitario Gregorio Marañón. 
Universidad Complutense de Madrid, España. 

Manuel Segovia 
Hospital Clínico Universitario Virgen de la Arrixaca. 
Universidad de Murcia, España.

9:45 h.

Legionella from virulence to control

Moderator: 
Basilio Valladares 

Instituto Universitario de Enfermedades Tropicales y Salud Pública. 
Universidad de La Laguna. España.

 

The life cycle of Legionella pneumophila is linked to virulence

Carmen Buchrieser 
Institut Pasteur, Biologie des Bactéries Intracellulaires, Paris, France.

 

Free-living ameobae-bacteria predation dynamics shifts the drinking water biofilm community to favor opportunistic water-based pathogens

Mohamed Shaheen 
Alberta Innovates Translational Health Chair in Water. 
School of Public Health, University of Alberta, Canada. 

 

Ending Legionnaires' disease: audacious or achievable goal?

Janet E. Stout  
Special Pathogens Laboratory, USA. 
University of Pittsburgh Swanson School of Engineering, USA. 

11:45 h.

Break

12:15 h.

The legionelosis from the clinical perspective

Moderator: 
Emilio Bouza 

Consejo Científico de la Fundación Ramón Areces 
Hospital Universitario Gregorio Marañón. 
Universidad Complutense de Madrid, España.

 

Legionnaires' disease: Clinical aspects

Patricia Muñoz 
Hospital Universitario Gregorio Marañón. 
Universidad Complutense de Madrid, España.

 

Diagnostic testing for legionnaires´disease

Concha Gimeno 
Consorcio Hospital General Universitario de Valencia. 
Universidad de Valencia, España.

13:30 h.

Break

16:00 h.

Legionella, current epidemiological situation and control

Moderator: 
José Prieto Prieto 

Universidad Complutense de Madrid. España. 

 

Legionella, epidemiological situation in Spain

Rosa Cano 
Centro Nacional de Epidemiología, Instituto de Salud Carlos III, Madrid, España.

 

Management of legionellosis outbreaks

Herme Vanaclocha 
Dirección General de Salud Pública (Generalitat Valenciana), Valencia, España.

 

Facilities management and Legionella control

Vicente Catalán 
Labaqua. Alicante, España.

 

Legislative challenges for the control of Legionella

Covadonga Caballo Dieguez 
Subdirectora General de Sanidad Ambiental y Salud Laboral. 

 

Discussion

18:30 h.

Closing remarks

Manuel Segovia   
Hospital Clínico Universitario Virgen de la Arrixaca. 
Universidad de Murcia, España. 

Emilio Bouza  
Consejo Científico de la Fundación Ramón Areces. 
Hospital Universitario Gregorio Marañón. 
Universidad Complutense de Madrid, España.

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