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New Insights in Cancer Discovery 2022

Life and Matter Sciences International Symposium Monday and Tuesday, 7 and 8 March 2022, 10:00 hours Madrid

General information:

Venue: Fundación Ramón Areces - salón de actos. Calle Vitruvio, 5. 28006. Madrid.

Organized with Centro Nacional de Investigaciones Oncológicas (CNIO) and Instituto Weizmann de Ciencias 

Free admission. Necessary previous online registration. Limited capacity. 

  • Description
  • Programme

Despite all the outstanding advances in therapy, diagnostics and prevention that have taken place during the last few decades, cancer remains as one of the leading causes of death worldwide. The only way to make effective progress towards satisfying this unmet medical need, providing new hopes to patients and their families, is through the intensification of research activities that may provide new hints on the mechanisms behind cancer initiation and progression, which can then be translated into new approaches to develop effective treatments and diagnostic tools.

This CNIO – Weizmann Institute of Science 3rd Joint Symposium will bring together a number of international experts from the CNIO and the Weizmann Institute of Science working in diverse fields related to cancer research, to share the latest results from their laboratories. The participants will cover a broad diversity of topics which are considered to be key to improve our understanding of the intimate mechanisms driving cancer.

Thus, this symposium will focus particularly in diverse aspects related to genome and chromosome instability and its relation with cancer, the importance of the tumor microenvironment and the interactions between the tumor and its host, the analysis of tumor heterogeneity, the relevance of mutations in key tumor suppressors, or the role of the innate immune system in tumor detection.

Monday,  7 March

9:30 h.

Attendees check-in

10:00 h.

Opening Remarks 

Raimundo Pérez-Hernández y Torra 
Director Fundación Ramón Areces.

Emilio Bouza 
Chairman of Fundación Ramón Areces Scientific Committee.

María Blasco 
Spanish National Cancer Research Center (CNIO).

Moshe Oren 
Weizmann Institute of Science (WIS).

 10:30 h.

DNA damage tolerance based on re-priming: mechanisms and implications for cancer therapy

Juan Méndez
DNA Replication Group Leader (CNIO).

11:00 h.

Identifying amino-acid crosstalks between the tumor and the host for improving cancer diagnosis and therapy  

Ayelet Erez
Weizmann Institute of Science (WIS).


11:30 h.


 12:00 h.

Stress and mutation dependencies in the tumor microenvironment

Ruth Scherz-Shouval
Weizmann Institute of Science (WIS).

12:30 h.

DNA supercoiling and topoisomerases in genome organization and transcriptional control

Felipe Cortés
Topology and DNA Breaks Group Leader (CNIO).

13:00 h.

Proteomic analysis of cancer internal heterogeneity

Tamar Geiger
Weizmann Institute of Science (WIS).


13:30 h.


 14:30 h.

Dissecting Cohesin complex biology in development and cancer

Ana Losada
Chromosome Dynamics Group Leader (CNIO).

15:00 h.

Love thy neighbor – unraveling the tumor immune microenvironment by multiplexed imaging 

Leeat Keren
Weizmann Institute of Science (WIS).­­­­­­­

 15:30 h.

Caught in the act. Visualising the elusive mismatch repair machinery by cryoEM

Rafael Fernández-Leiro
Genome Integrity and Structural Biology Junior Group Leader (CNIO).


Tuesday, 8 March

10:00 h.

Attendees check-in

 10:30 h.

Order from Chaos: Chromosome Catastrophes Drive Cancer Evolution

Ofer Shoshani
Weizmann Institute of Science (WIS).

11:00 h.

A pan-cancer compendium of chromosomal instability 

Geoff MacIntyre 
Computational Oncology Junior Group Leader (CNIO).

 11:30 h.

Some p53 mutations are more equal than others

Moshe Oren
Weizmann Institute of Science (WIS).

12:00 h.

Myeloid cells, innate immune sensors in tumor initiation  

María Casanova
Cancer and Immunity Junior Group Leader (CNIO).

12:30 h.

Closing Remarks 

María Blasco 
Spanish National Cancer Research Center (CNIO).

Moshe Oren 
Weizmann Institute of Science (WIS).

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