Jump Main Menu. Go directly to the main content

Sección de idiomas

EN

Fin de la sección de idiomas

Sección de utilidades

Calendar

Fin de la sección de utilidades

Scholarships and grants

Secondary menu End of secondary menu

Research projects

Start of main content

Analysis using genetically modified mice of the possible role of alpha-synuclein in the pathogenesis of Huntington's disease

15th National Programme for the allocation of Research Grants for Life and Matter Sciences

Rare diseases

Senior Researcher : José Javier Lucas Lozano

More information

Research Centre or Institution : Centro de Biología Molecular "Severo Ochoa". CSIC-Universidad Autónoma de Madrid

Abstract

Huntington's disease (HD) is caused by polyglutamine expansion in the huntingtin protein that leads it to aggregate and form inclusion bodies (IBs). IBs are a common feature of neurodegenerative diseases. In the case of Parkinson's disease, they are formed by the alpha-synuclein (a syn) protein. Because there are hereditary forms of Parkinson's disease due to mutations (point or duplication mutations) of a syn in the gene, it is known that alterations in the aggregation or levels of a syn are sufficient to cause neurodegeneration. Based on the preliminary results of co location of a syn in the IBs of patients and animal models for HD, it was hypothesised that a syn is a key mediator in the pathogenesis of HD. The main objective of the proposal is, therefore, to generate and analyse transgenic mice with HD with different gene doses of a syn.

  • Activities related
  • Projects related
  • News related
  • Publications related

see past activities

see all

End of main content

Share