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Association between non-coding RNAs in ultra-conserved regions (T-UCR) and the epigenome: involvement in cancer

15th National Programme for the allocation of Research Grants for Life and Matter Sciences

The genome and epigenome

Senior Researcher : Manel Esteller Badosa

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Research Centre or Institution : Epigenetics and Cancer Biology Program. Bellvitge Biomedical Research Institute (IDIBELL). Barcelona. (Spain)

Abstract

Epigenetic alterations contribute to the onset and progression of tumours. Recently, it has been established that non-coding RNAs are key elements involved in the biology of healthy cells and the development of several diseases, including cancer. The best studied non-coding RNAs are microRNAs, but the other non-coding RNAs that have emerged with great interest are T-UCRs ("ultraconserved regions"). This project seeks to determine whether T-UCRs are regulated epigenetically, both at the level of DNA methylation and histone modification, and by miRNAs, items that are altered in cancer and whose degree of contribution to the human tumerogenesis process is still a matter to be resolved. Research in this sense offers the opportunity to discover new mechanisms and signal transduction pathways altered in cancer, as well as the identification of new molecular markers and new therapeutic agents.

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