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Biotechnological basis for the development of functional foods in the field of intestinal maturation, inflammatory bowel disease and irritable bowel syndrome

15th National Programme for the allocation of Research Grants for Life and Matter Sciences

Biotechnology for functional food

Senior Researcher : Fermín Sánchez de Medina López-Huertas

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Research Centre or Institution : Facultad de Farmacia. Universidad de Granada


The project aims to establish a solid foundation for the application of functional foods to various intestinal diseases. The project focuses on two intestinal diseases: inflammatory bowel disease and irritable bowel syndrome, as well as intestinal maturation in newborns. Specifically: (1) The intestinal anti-inflammatory activity of the routine glycomacropeptide and 3 non-absorbable glucides will be assessed in the lymphocyte transfer model in mice. This is important because the models used to date are not strictly chronic and require validation in a lymphocyte-mediated model rather than an innate immunity model. (2) The potential therapeutic effect of these compounds will be studied in an irritable bowel syndrome model. Although its pathology is complex and poorly understood, it is believed that there is a certain underlying inflammatory component, validating the working hypothesis that there may be a therapeutic effect. (3) The study will complement the effects on intestinal maturation of those compounds for which data are still lacking in this regard. In all cases functional and biochemical analysis will be performed as well as a genomic study using post-genomic microarray and validation by quantitative PCR. 

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