Research projects
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Exosome optimisation for therapeutic use. The role of tetraspan in-rich micro domains in the biogenesis and function of exosomes
17th national competition for scientific and technical research
Exosomes: intercellular communication as a therapeutic weapon
Research Centre or Institution : Centro de Biología Molecular "Severo Ochoa". CSIC-Universidad Autónoma de Madrid
Abstract
Recent interest in exosomes derives from their characterisation as intercellular communication initiators able to mediate the horizontal and systemic transfer of genetic and protein material. In spite of its great potential in therapy and as non-invasive biomarkers of disease, there is little information about the molecular mechanisms that determine their biogenesis, binding and capture by target cells, or their function. The tetraspanins, which form microdomains that bind to the plasmatic membrane, are the most abundant proteins on the surface of exosomes. This project has the aim of using the large battery of tools against tetraspanins and their associated molecules created in our laboratory to study their functional role in the biogenesis and function of exosomes. With all of this we aim to gain deeper knowledge of exosome functions. This information is crucial to optimise therapies based on these exocytic vesicles, given that they will reveal new molecular targets that will allow us to either block their secretion, to reduce their metastatic and angiogenic capacities, or to increase their stability or immunoregulatory capacity.
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10
Mar
2020
International Symposium Membrane-Less Organelles in Cell Life and Disease POSTPONED Sevilla, Tuesday and Wednesday, 10 and 11 March 2020, 9:00 hours
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12
Sep
2022
Conferencia online Diseño de materia supramolecular para señalar y emular sistemas vivos ONLINE www.fundacionareces.tv/directo, Monday, 12 September 2022, 19:00 hours
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9
May
2024
Conference Genes de mosca y genes humanos: una comparación Madrid, Jueves 09 de mayo de 2024, 19:00 horas
- Regeneration as a model to identify molecular mechanisms involved in cellular reprogramming 2016 Senior Researcher : Antonio Baonza Cuenca Research Centre or Institution : Centro de Biología Molecular "Severo Ochoa". CSIC-Universidad Autónoma de Madrid
- Study of EBV, HHV-6A AND HHV-6B MICRO-RNAs in plasma isolated exosomes of patients with multiple sclerosis: correlation with activity and progression of disease 2016 Senior Researcher : Roberto Álvarez Lafuente Research Centre or Institution : Hospital Universitario Clínico San Carlos. Instituto de Investigación Sanitaria San Carlos (IdISSC). Madrid.
- Modulation of exosomes transporting miRNAs and lncRNAs for intercellular communication as therapeutic tools in dyslipidemia treatment 2016 Senior Researcher : Alberto Dávalos Herrera
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