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Exosomes: new intercellular communicators and their use as therapeutic agents in untreated parasitic diseases
17th national competition for scientific and technical research
Exosomes: intercellular communication as a therapeutic weapon
Research Centre or Institution : Centro de Investigación en Salud Internacional de Barcelona (CRESIB)
Abstract
Exosomes are nano-vesicles measuring 30-100 nm composed of two lipid layers and generated by the endocytosis of plasmatic membrane segments. It is surprising that until recently exosomes were practically unknown, and were thought to be subproducts of cell metabolism. This perception has changed radically, given their newly discovered role as mediators involved in transmitting biological signals, as well as their potential in diagnostics and new therapeutic strategies in cancer and other diseases, including parasitic ones. In this proposal we hypothesise that exosomes deriving from untreated diseases caused by three human parasites, malaria vivax, Chagas and fascioliasis, act as cell intercommunicators facilitating the establishment of infections. Moreover, parasitic proteins in these exosomes will identify new antigens for vaccinations, and the use of exosomes will make it possible to create a new platform of nanovaccines against the aforementioned parasites.
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17
Oct
2019
International Symposium Proteostasis and protein secretion Madrid, Thursday and Friday, October 17 and 18, 2019 9:15 hours
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10
Mar
2020
International Symposium Membrane-Less Organelles in Cell Life and Disease POSTPONED Sevilla, Tuesday and Wednesday, 10 and 11 March 2020, 9:00 hours
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12
Sep
2022
Conferencia online Diseño de materia supramolecular para señalar y emular sistemas vivos ONLINE www.fundacionareces.tv/directo, Monday, 12 September 2022, 19:00 hours
- Study of EBV, HHV-6A AND HHV-6B MICRO-RNAs in plasma isolated exosomes of patients with multiple sclerosis: correlation with activity and progression of disease 2016 Senior Researcher : Roberto Álvarez Lafuente Research Centre or Institution : Hospital Universitario Clínico San Carlos. Instituto de Investigación Sanitaria San Carlos (IdISSC). Madrid.
- Modulation of exosomes transporting miRNAs and lncRNAs for intercellular communication as therapeutic tools in dyslipidemia treatment 2016 Senior Researcher : Alberto Dávalos Herrera
- Characterization of infection biomarkers and possible drug targets present into exosome vesicles generated during in vitro and in vivo infection by Leishmania infantum 2016 Senior Researcher : Vicente Emilio Larraga Rodríguez de Vera Research Centre or Institution : Centro de Investigaciones Biológicas (CSIC)
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