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Immunity and atherosclerosis. New connections between the lipidic metabolism and microbial infections
14th national competition for scientific and technical research
Cellular and molecular mechanisms of atherosclerosis
Senior Researcher : Antonio Castrillo Viguera
Research Centre or Institution : Facultad de Medicina. Universidad de Las Palmas de Gran Canaria
Abstract
Cardiovascular disease and type 2 diabetes are currently the leading cause of death and morbidity in the industrialised world. Obesity, high blood pressure, insulin resistance and inflammation are decisive factors in the development of arteriosclerosis. Therefore, the physiopathological study of these metabolic and immune symptoms has become a priority objective for biomedicine. In this respect, our project will endeavour to study in greater depth the connections between the immune system and cholesterol metabolism, through different cellular and animal models.
More specifically, the Liver X Receptors, LXR-alpha and LXR-beta are members of the superfamily of nuclear receptors that play an essential role in cholesterol metabolism in vertebrates. In general, LXR activation generates changes that are considered anti-atherosclerotic, eliminating cholesterol from the arteries by increasing the "good cholesterol, HDL". However, bacterial and viral infections can inhibit the metabolic activity of LXR, which could be considered as having a detrimental effect and can accelerate cardiovascular disease. Our project will study this hypothesis and will analyse the molecular mechanisms that link lipidic metabolism and infections.
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17
Oct
2019
International Symposium Proteostasis and protein secretion Madrid, Thursday and Friday, October 17 and 18, 2019 9:15 hours
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10
Mar
2020
International Symposium Membrane-Less Organelles in Cell Life and Disease POSTPONED Sevilla, Tuesday and Wednesday, 10 and 11 March 2020, 9:00 hours
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12
Sep
2022
Conferencia online Diseño de materia supramolecular para señalar y emular sistemas vivos ONLINE www.fundacionareces.tv/directo, Monday, 12 September 2022, 19:00 hours
- Study of EBV, HHV-6A AND HHV-6B MICRO-RNAs in plasma isolated exosomes of patients with multiple sclerosis: correlation with activity and progression of disease 2016 Senior Researcher : Roberto Álvarez Lafuente Research Centre or Institution : Hospital Universitario Clínico San Carlos. Instituto de Investigación Sanitaria San Carlos (IdISSC). Madrid.
- Modulation of exosomes transporting miRNAs and lncRNAs for intercellular communication as therapeutic tools in dyslipidemia treatment 2016 Senior Researcher : Alberto Dávalos Herrera
- Characterization of infection biomarkers and possible drug targets present into exosome vesicles generated during in vitro and in vivo infection by Leishmania infantum 2016 Senior Researcher : Vicente Emilio Larraga Rodríguez de Vera Research Centre or Institution : Centro de Investigaciones Biológicas (CSIC)
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