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Integration and modelling of the metabolism and biological effects of the biogenic amines, biomolecules directly involved in rare and emerging diseases
14th national competition for scientific and technical research
Rare diseases
Senior Researcher : Miguel Ángel Medina Torres
Research Centre or Institution : Facultad de Ciencias. Universidad de Málaga
Abstract
Histamine plays a fundamental role in many rare or emerging immunity-related diseases (such as mastocytosis, basophilic leukemias and a variety of inflammatory and neurological diseases). Additionally, this same amine, together with the polyamines derived from arginine, regulate the proliferation and differentiation of very diverse types of cells. The fundamental aim of the project is to use biocomputational strategies in the localisation of specific targets in the metabolism of these amines, their individual elements (enzymes) and the signalling networks of their expression and biological function, which would provide key information (at a minimal cost) to better understand the molecular foundations of these processes and, particularly, for the development of more efficient therapeutic (or diagnostic) strategies to fight against the diseases in which these molecules play a significant role, most of which are rare or emerging immune system, dermatological, gastrointestinal and neurological diseases.
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30
Jan
2020
International Symposium Understanding and reprogramming developmental visual disorders: from anophthalmia to cortical impairments Madrid, Thursday and Friday, 30 and 31 January 2020, 9:30 hours
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8
Apr
2024
Panel Discussion Mundo de las prótesis, los nuevos materiales, sus complicaciones y su futuro Madrid , Lunes, 8 de abril 2024. 17.00 horas
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23
Apr
2024
Session Situación actual de las Enfermedades Raras en España Madrid, Martes, 23 de abril de 2024, 10:00 horas
- Phenotyping of animal models of rare diseases with visual disability 2020 Senior Researcher : Lluís Montoliu José Research Centre or Institution : Centro Nacional de Biotecnología (CNB). CSIC. Madrid
- The neuronal glycine transporter GlyT2 in herplexia: a glycinergic pathology of development 2020 Senior Researcher : Beatriz López Corcuera Research Centre or Institution : Centro de Biología Molecular Severo Ochoa. CSIC - UAM
- Serum markers in patients with congenital melanocytic nevi: clinicopathological and genetic correlation 2020 Senior Researcher : Pedro Redondo Bellón Research Centre or Institution : Clínica Universidad de Navarra. Pamplona
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