Research projects

Currently, there are no widely available blood tests that reliably identify biomarkers for the diagnosis or monitoring of Parkinson’s disease (PD), even in its later stages. This limitation delays the early application of treatments that could slow disease progression, making the discovery of blood-based biomarkers essential for early diagnosis and treatment monitoring. Although PD primarily affects the central nervous system, its effects can also be observed in the blood, making it a potential source of valuable biomarkers. This project explores whether peripheral blood cells, such as leukocytes, display unique molecular characteristics in PD. These may include changes related to oxidative stress, inflammation, and antioxidant responses, potentially distinguishable from individuals without neurological symptoms. The objective is to identify a panel of genes or markers in blood that can differentiate individuals with PD from those without. Our multidisciplinary team combines basic neuroscientists and clinical neurologists with extensive expertise in neurodegeneration research. With our clinicians diagnosing and monitoring numerous PD cases in Spain, we are well-positioned to translate preclinical therapies into clinical practice, while exploring oxidative and inflammatory signatures as potential PD biomarkers. Success could lead to significant advancements in diagnostic tools, therapeutic strategies, and healthcare systems, addressing the substantial social and economic challenges posed by this progressive neurodegenerative disease.