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Progression of different forms of multiple sclerosis related to the stem/progenitor cells potential

19th national competition for scientific and technical research

Amyotrophic Lateral Sclerosis (ALS) and Multiple Sclerosis (MS): Molecular Etiology and Novel Treatments

Senior Researcher : Laura López Mascaraque

Research Centre or Institution : Instituto Cajal. CSIC. Madrid.

Abstract

The loss of myelin and oligodendrocytes in the adult central nervous system is a hallmark of demyelinating diseases such as multiple sclerosis (MS). However, to date there are not treatments oriented to remyelinate and to repair the loss of the myelin-forming oligodendrocytes. On the other hand, there are evidences showing that the brain response its different depending on the environment: pathological situation, injured area, degree of inflammation etc. This indicates that probably the generation of new oligodendrocytes from both, resident OPCs/NG2 (oligodendrocytes precursor cells homogeneously distributed in the adult brain) and SVZ progenitor cells, is altered depending on the MS type. The long-term goal of this research is to determine the generation of OPCs!NG2- cells in diverse demyelinating scenarios to decipher the lack of the spontaneous remyelination in MS patients. Then, since it is unknown the factors that determine the OPCS/NG2 in MS, we propase to address the clonal response of OPCs/NG2 progeny through StarTrack labelling of individual progenitor cells to follow their progeny in the different demyelinating animal models. In addition, we will analyse post-mortem brain of MS patients with different MS progression to explore whether the possible changes of SVZ and in OPCs/NG2 distribution will be correlated with the clinical evolution of the patients.

The possible changes of SVZ and in the NG2 cells distribution probably correlate with the clinical evolution of the patients. These results will have a great therapeutic value in the in the search of new treatments that promete remyelination in these patients and may help clarify the mechanisms potentially involved in MS.

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