Research projects
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Role of chemokines in differentiating monocytes from macrophage/spongy cells and reverse transendothelial migration, in the early stages of arteriosclerosis
14th national competition for scientific and technical research
Cellular and molecular mechanisms of atherosclerosis
Research Centre or Institution : Fundación para la Investigación Biomédica del Hospital Gregorio Marañón. Madrid
Abstract
Arteriosclerosis is a chronic inflammatory disease. Arteriosclerosis is a progressive disease characterised by the accumulation of fat on arterial walls. In the early stages of the disease, the arterial wall becomes infiltrated by inflammatory cells (monocytes) which devour fat and are transformed into spongy cells, thereby producing "striae". Certain studies carried out in children indicate that this early damage tends to disappear, which suggests that inflammatory cells migrate from the vascular wall towards the bloodstream. The migration of inflammatory cells towards the vascular wall is controlled by chemotactic factors (which attract) and the migration of tissue cells towards the bloodstream may be influenced by chemorepulsion factors (which repel). In this project we undertake to analyse the role of attraction factors (chemokines) in the transformation of monocytes into spongy cells (formation of the arteriosclerotic plaque). We will also study the possible reverse migration of inflammatory cells from the vascular wall towards the bloodstream (treatment of striae). Knowledge of the molecular and cellular mechanisms that regulate these processes will enable the development of new therapeutic approaches aimed at the prevention and control of arteriosclerosis.
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17
Oct
2019
International Symposium Proteostasis and protein secretion Madrid, Thursday and Friday, October 17 and 18, 2019 9:15 hours
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10
Mar
2020
International Symposium Membrane-Less Organelles in Cell Life and Disease POSTPONED Sevilla, Tuesday and Wednesday, 10 and 11 March 2020, 9:00 hours
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12
Sep
2022
Conferencia online Diseño de materia supramolecular para señalar y emular sistemas vivos ONLINE www.fundacionareces.tv/directo, Monday, 12 September 2022, 19:00 hours
- Study of EBV, HHV-6A AND HHV-6B MICRO-RNAs in plasma isolated exosomes of patients with multiple sclerosis: correlation with activity and progression of disease 2016 Senior Researcher : Roberto Álvarez Lafuente Research Centre or Institution : Hospital Universitario Clínico San Carlos. Instituto de Investigación Sanitaria San Carlos (IdISSC). Madrid.
- Modulation of exosomes transporting miRNAs and lncRNAs for intercellular communication as therapeutic tools in dyslipidemia treatment 2016 Senior Researcher : Alberto Dávalos Herrera
- Characterization of infection biomarkers and possible drug targets present into exosome vesicles generated during in vitro and in vivo infection by Leishmania infantum 2016 Senior Researcher : Vicente Emilio Larraga Rodríguez de Vera Research Centre or Institution : Centro de Investigaciones Biológicas (CSIC)
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