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Study of the possible immunomodulation caused by Anisakis simplex larval antigens

15th National Programme for the allocation of Research Grants for Life and Matter Sciences

Rare diseases

Senior Researcher : María del Carmen Cuéllar del Hoyo

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Research Centre or Institution : Facultad de Farmacia. Universidad Complutense. Madrid

Abtract

The experimental hypothesis of this paper is that the larval products of Anisakis simplex may be immunosuppression mediators, trapped by dendritic cells (DCs) in the mucosa, that produce tolerogenic signals capable of inducing expansion of CD4+ T lymphocyte sub-populations with a regulator function. The aim is to study the effect of A. simplex larval antigens on the role of DCs and CD4+ T lymphocytes and later how the parasite antigens affect the physiology of DCs to initiate a tolerogenic response. As antigens, total larval products and excretion-secretion products of third-stage larvae of A. simplex will be used. Mouse models will be used since the tolerogenic DCs and T reg lymphocyte sub-classes are similar to human ones in phenotype and function.

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