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The structural bases of tumoral development associated with transcription regulating interactome defects

17th national competition for scientific and technical research

Interactome: pathological implications

Senior Researcher : Carlos Fernández Tornero

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Research Centre or Institution : Centro de Investigaciones Biológicas (CIB) (CSIC)


The transcription or synthesis of ARN is the first step in gene expression. It is regulated through a dynamic network of interactions between the macromolecules involved in the aforementioned process. Transcriptional alterations have an enormous impact on cellular homeostasis and are directly connected with the development of diseases. Loss of control of cellular proliferation stands out among these, and generally leads to the formation of tumours. An in-depth study of the interactions that regulate this process would therefore make it possible to lay the foundations for the development of new anti-tumoral drugs.

The aim of this project is the structural and functional characterisation of a series of proteins and macromolecular complexes involved in the synthesis of ARN. The project we propose aims to meet this challenge by using an innovative structural approach that combines several experimental techniques to offer a holistic vision of the process. Our approach combines powerful structural methods such as x-ray crystallography and electronic microscopy, genetic studies and classical biochemical studies, together with emerging techniques such as wild-type mass spectroscopy. Our studies will contribute to a better understanding of how ARN synthesis is regulated, as well as developing strategies to study protein complexes and their interactions with other macromolecules.

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