Research projects

2024

more information on Development and Application of saRNAs for the Treatment of Rare Monogenic Diseases

2024

more information on CHANNELOSOME RESCUING PEPTIDES IN THE TREATMENT OF ARRHYTHMIAS IN INHERITABLE HEART DISEASES

2024

more information on Mechanisms for sustaining mitochondrial genome integrity and function during hematopoiesis.

2024

more information on Biocompatible nanoformulations: targeted delivery of bioactive compounds for the treatment of Inborn Errors of Metabolism

2024

more information on In vitro and in vivo correction via gene editing of frequent pathogenic variants in neurometabolic diseases

2024

more information on “Artificial Antigen Presenting Cell-based expansion of allogenic CD4+ Virus Specific T cells: towards a new generation of Adoptive Cell Therapies” (aAPC-4VST)

2024

more information on Dietary neuro-immunomodulation of metastasis

2024

more information on Personalized therapies in ovarian cancer to overcome resistance

2024

more information on Molecular Intersect of Autophagy and LINE-1 Retrotransposons Regulation During Aging

2024

more information on Peripheral Redox and Inflammation Signatures for Biomarker Discovery in Parkinson's Disease.

2024

more information on GRK2 interactomes involved in reshaping macrophage metabolic and inflammatory networks during obesity and type 2 diabetes

2024

more information on Cell interactions leading to tumorigenesis: Role of senescent cells

2024

more information on Development of Neuroprotective Nanoingredients from Olive Oil Industry By-Products

2024

more information on Retos en la reutilización en el medio agrícola: un enfoque “OneHealth” en la lucha contra la diseminación de antibióticos, bacterias resistentes y genes de resistencia

2024

more information on Valorization of Carbon Dioxide and Dinitrogen by Cooperative Bimetallic Catalysts

2024

more information on CLaCoS - Deciphering Climate Change: Lagrangian Coherent Structures in Atmospheric and Oceanic Flows as Indicators.

2024

more information on Neurorregeneración en la enfermedad de Alzheimer a través de la expresión de factores de pluripotencia in vivo

2024

more information on Unveiling a novel intercellular dialogue: mitochondria transfer to B cells during the immune response

2024

more information on Dynamic Liquid-Crystal Colloids with Biomimetic Actuation, Recognition, and Adaptation

2024

more information on New (multi-)printable materials for the development of sustainable and biocompatible reactive patches in biomedical applications (ZymoMat)

2024

more information on Deciphering unfolded protein response and its immune suppressive role in high grade B cell lymphomas

2024

more information on Digitalización avanzada de sistemas energéticos renovables

2024

more information on EphB3: a new therapy for osteoporosis and bone fractures

2024

more information on Programmable hybrid biomaterials via click chemistry: Sponge biomimetic tubules as chemobrionic scaffolds for cell culture

2024

more information on Evalua&ng the An&tumor Poten&al of Chaperonin CCT modulators

2024

more information on Improvement of Diagnosis and Neonatal Screening of Hereditary Metabolic Diseases Using Untargeted Metabolomics

2024

more information on Caracterización multiómica de Escherichia coli verotoxigénico para el diagnóstico clínico del Síndrome Hemolítico Urémico en la infancia y monitorización integrada de la granja al paciente.

2024

more information on ldentifying novel determinants of clonal haematopoiesis progression: towards early detection of cancer risk

2024

more information on Light materials for next generation electronics

2024

more information on Protocol for the early diagnosis of acute myeloid leukemia based on the interactome of dimethylated cytochrome c

2022

more information on Renewable Ammonia as an Energy Vector

2022

more information on Programming bacterial metabolism for the valorization of plastic wastes (ProgStrain):

2022

more information on Harnessing microRNAs for cancer immunotherapy

2022

more information on Non-atherosclerotic thrombosis and multiorgan damage in Hutchinson-Gilford progeria syndrome: From mechanism to therapy

2022

more information on In vivo neuronal precise reprogramming and rejuvenating in Alzheimer’s disease

2022

more information on Pulmonary surfactant-based nanomedicines for lung-targeted therapies (Nanosurf)

2022

more information on Multifunctional nanomaterials for the treatment of osteoarticular prosthesis infections (Nano4Infection)

2022

more information on Trophoblast Invasion: New Insights into Cancer Metastasis using Human Placenta

2022

more information on Gαq interactome in cell homeostasis and communication: impact on tissue architecture remodeling and endothelial dysfunction

2022

more information on Identification at single-cell level of molecular and metabolomic mechanisms governing antitumoral response of CAR T therapies in MM patients (M4CART)

2022

more information on Targeting extracellular vesicle mediated intercellular communication: a rational approach for the treatment of cancer metastasis

2022

more information on Multiple Acyl-CoA Dehydrogenases Deficiency (MADD): a preclinical animal model and a rational approach for drug design targeting mitochondrial metabolism

2022

more information on Transgenerational and epigenetic consequences of dietary intake of nanoplastics

2022

more information on Study of the role of RNA methylation in transposable element control during aging (RNAMETAGEING)

2022

more information on Circulating exovesicles as markers of early diagnosis of CHAGas disease (PRECHAG).

2022

more information on Ultra-Bright Open Cavity Photon Sources (ULTRA-BRIGHT)

2022

more information on Gut-Finder, an AI-based technology to Promote Healthy Aging

2022

more information on Pushing the Boundaries of CO2 electrocatalysis to fuels using Automatized Catalyst Development (ElectroFuel)

2020

more information on Phenotyping of animal models of rare diseases with visual disability

2020

more information on Thermoelectric micro-generator to obtain portable and sustainable energy

2020

more information on Understanding the connection between ROS/RNS homeostasis and the circadian signalling network: beyond the genetic level

2020

more information on Biointeractomics on DNA Damage Response in Homeostasis and Disease

2020

more information on Immediate and universal diagnosis of infectious diseases based on optomechanical capillaries

2020

more information on Mammalian-bacterial cell interaction: the role of sphingolipids, and a novel investigate approach

2020

more information on Dissecting the role of the hepatocyte Epidermal Growth Factor Receptor (EGFR) pathway in the cellular interactome within the liver fibrotic niche

2020

more information on Role of mitochondrial disfunction in the energy collapse associated to aging and frailty. Basci an translational aspects

2020

more information on Impacts of climate change on bioelemental stocks and flows and feedbacks on ecosystems and crops – ELEMENTAL CLIMATE

2020

more information on The neuronal glycine transporter GlyT2 in herplexia: a glycinergic pathology of development

2020

more information on Tumor microbiome and immune profiles as predictors of treatment response in high-risk non-muscle invasive bladder cancer (MIT-BC Study)

2020

more information on Spanish National Brain Metastasis Network (RENACER): Implementation, Development and Coordination

2020

more information on Exploring post-translational regulation of angiogenic and inflammatory-related processes during colorectal cancer progession and differential recurrence

2020

more information on Serum markers in patients with congenital melanocytic nevi: clinicopathological and genetic correlation

2020

more information on Regioselective manipulation of carbon spheres to revolutionize the efficiency of solar cells (RegioSolar)

2020

more information on Propionic acidemia: impact on the epigenome and the proteome in relation to the cardiac and neurological phenotype

2020

more information on Nutritional formulae for docosahexaenoic acid (DHA) and arachidonic (AA) deficiency control in extreme premature infants

2020

more information on Molecular imaging of the infection by Clostridiodes difficile

2020

more information on Age-related Hearing loss and Dementia

2020

more information on Cell-derived EXOsomes engineering with microFLUIDics for efficient Targeted Therapies: ExoFluidTT

2020

more information on Effects of static magnetic fields on the brain: study of the mechanisms

2020

more information on Characterization of macromolecular targets as a key to understanding, diagnosis and design of therapies in rare diseases

2018

more information on Dissecting a neuron-to-liver crosstalk to modulate lipid metabolism in Batten disease

2018

more information on Gene therapy to correct glutaric aciduria type 1 in Gcdh -1- mice

2018

more information on Systems medicine applied to the identification of new therapeutic targets in rare genetic-based diseases

2018

more information on Advanced gene editing technologies to restore LAMA2 on merosin-deficient congenital muscular dystrophy type 1A

2018

more information on Molecular mechanisms underlying Zic2-associated holoprosencephaly

2018

more information on New insights on Aicardi-Goutieres Syndrome, a novel connection with DNA repair

2018

more information on Artificial intelligence and machine learning in human diseases

2018

more information on Novel immunotherapeutic strategies against T-ALL, a rare pediatric disease

2018

more information on Therapeutic strategy against Huntington's disease through the synergistic activation of AMPK

2018

more information on Molecular mechanisms in the development of scoliosis in limb-girdle muscular dystrophies

2018

more information on Integration of genomic and epigenomics strategies for the analysis of T lymphoblastic neoplasms in the context of a precision individualized medicine

2018

more information on Developing a targeted therapy to promote melanoma immune-recognition and suppress metastasis

2018

more information on Precision medicine approach to target deregulated metabolism in multiple myeloma

2018

more information on p38α in control of UV-induced melanoma development and progression

2018

more information on Precision medicine: GEF activators of the SOS family as therapeutic targets in Ras-dependent tumors

2018

more information on Identification of novel immunotherapeutic targets in lung and melanoma brain metastases

2018

more information on Reactive astrocytes as a therapeutic target in brain metastasis

2018

more information on Heterogeneity in melanoma metastasis and resistance to immune checkpoint blockade

2018

more information on Synthetic nanoparticles as an innovative treatment for sepsis (SPRINT-4-SEPSIS)

2018

more information on Risk Assesment of Bacterial Sepsis using multiomic and bioinformatics tools: an approach towards the Precision Medicine in Infectious Diseases

2018

more information on Extracellular vesicles biomarkers for the diagnosis and prognosis of post-surgical septic shock

2018

more information on Significance of brain glucose hypometabolism and of altered insulin signal transduction in an experimental model of amiotrophic lateral esclerosis (ALE)

2018

more information on Investigation on hybrid molecules as powerful novel therapeutic approaches for Multiple Sclerosis and myelin- related rare diseases

2018

more information on Progression of different forms of multiple sclerosis related to the stem/progenitor cells potential

2018

more information on Functional characterization and mechanisms of the signalling kinase MOK in neuroinfiammation associated to Amyotrophic Lateral Sclerosis (ALS)

2018

more information on New messengers in the intreactome between hepatic and extra-hepatic cells in non' alcoholic fatty liver disease with diagnostic value

2018

more information on Interactome rewiring by phosphorylation and acetylation barcodes: implications in metabolic reprogramming in breast cancer

2018

more information on Identification and modelling of molecular and cellular events of the immune response associated to the appearance of minimal hepatic encephalopathy in cirrhotic patients

2018

more information on Interactome with the host cells of the Trypanosoma cruzi Exovesicles and the immunocomplexes; Implications in the pathology of the Chagas Disease

2018

more information on Comprehensive virus-host protein interactome by the use of yeast-two-hybrid coupled to next-generation sequencing analysis

2018

more information on Dynamic T cell centrosomal protein network controls exosome-mediated anti-pathogen activity in dendritic cells: FOSTER interactome

2018

more information on Microbiota, minerals and exposure to toxics interactions during the first 1000 days of life: identification of biomarkers and development of new dietary strategies

2018

more information on Production of second generation prebiotics and polyphenol glycosides. Validation of its bioactive properties for use in functional food

2018

more information on Biotechnological use of the circadian clock to obtain plants with improved productivity, nutritional quality and resilience to climate change

2018

more information on Nutritional strategies and bioactive compounds to target lipid metabolism alterations in cancer: Platform of Patient derived Paired Organoids for Precision Nutrition

2018

more information on Novel proton-conducting MOF composites for fuel cell devices

2018

more information on Nanostructured multifunctional membranes for the production of solar fuels by artificial photosynthesis

2018

more information on Beyond biogas as renewable energy source: conversion to methanol through metallic nanoparticles embedded in metal-organic frameworks (MOFs)

2018

more information on Graphene hot-carrier solar cell (SuGaR)

2018

more information on Magnetoplasmonic control (actuation and monitoring) of drug release using Fe/Au semi‐shells on biodegradable nanoparticles (MAGPLADRUG)

2018

more information on Controlled ultracold atomic arrays: a new platform for quantum technologies (CODEC)

2018

more information on Search for superconducting materials of high critical temperature

2016

more information on The function of the E3 ubiquitin ligase APC/C-Cdh1 in Fragile X Syndrome. Possible therapeutic application

2016

more information on A knowledge-based pipeline to increase the diagnosis rate of Rare Diseases using deep sequencing

2016

more information on Systemic analysis of the gene regulatory networks involved in the specification and maintenance of the retinal pigment epithelium: towards new therapies for retinal degenerative diseases

2016

more information on Dyskeratosis congenita. New models, New molecular keys and New treatments

2016

more information on Molecular basis of immune deficiency in Wolf-Hirschhorn Syndrome (4p-)

2016

more information on Visualisation of neuronal polysomal architecture and its alterations in Huntington's Disease

2016

more information on Modeling of familial cerebral cavernous malformation through cellular reprogramming

2016

more information on Phosphodiesterase inhibitors as Friedreich's ataxia treatment

2016

more information on Activation of innate immunity in dysferlin-deficient cells: new therapeutic targets

2016

more information on The connection between rare diseases and common diseases: dysfunction of copper homeostasis and mitochondria as a model (NeuroCopper)

2016

more information on Towards the improvement of diagnosis and treatment in Congenital Dyserythropoyetic Anaemias

2016

more information on Astrocytes: new anti-epileptic targets in Lafora disease

2016

more information on AGC1 deficiency and calcium signaling in mitochondria: a new disease model for the study of pathogenic mechanisms and for the development of therapeutic strategies

2016

more information on Genomic and transcriptomic study of circulating tumor lymphocytes for the development of biomarkers associated with the response to treatment with inhibitors of the PD-L1 / PD1 pathway in patients with NSCLC

2016

more information on Development of new targets for immunotherapy in cancer metastasis

2016

more information on Gene editing of key transcription factors to improve the antitumor efficacy of Adoptive T cell Therapy

2016

more information on Development and validation of an aerosol with intelligent nanoparticles in order to treat lung cancer

2016

more information on The Role of Dido in Lymphoid and Myeloid Development and Its Implications in Neoplasia

2016

more information on From preclinical models to the patient: a holistic investigation of immunotherapies in multiple myeloma

2016

more information on Transforming EGFR expressing tumors into immune-rejectable tissues

2016

more information on Development and preclinical testing of simultaneous dual engagement chimeric antigen receptors (SiDECARs) against acute myeloid leukemia

2016

more information on Study of EBV, HHV-6A AND HHV-6B MICRO-RNAs in plasma isolated exosomes of patients with multiple sclerosis: correlation with activity and progression of disease

2016

more information on Modulation of exosomes transporting miRNAs and lncRNAs for intercellular communication as therapeutic tools in dyslipidemia treatment

2016

more information on Characterization of infection biomarkers and possible drug targets present into exosome vesicles generated during in vitro and in vivo infection by Leishmania infantum

2016

more information on Applicability of exosomes as predictors of response to treatment and prognosis in breast cancer: cellular modifications induced by the interaction of exovesicles

2016

more information on Investigating the molecular mechanisms of exosome production under cellular stress

2016

more information on WIP differential interactome during its oncogenic or tumor suppressor activity

2016

more information on Role of the lysosomal protein LAMP2 in the AD-like phenotype induced by HSV-1: Study of the LAMP2 interactome in virus infected neurons

2016

more information on Interactions of the protein N-acetylglucosamine kinase with different elements of gene regulation in Yarrowia lipolytica

2016

more information on Identification of the nucleotide cellular sensor and its interactome

2016

more information on Development of therapeutic compounds based on the molecular interaction sites between the A238L viral protein and the transcriptional complexes that regulate the synthesis of pro-inflammatory and tumor mediators

2016

more information on Effect of mutations in the glucocerebrosidase-1 gene on iPS cell-derived neurons from Parkinson´s disease patients. Rescue of the phenotype and cell transplantation

2016

more information on Regeneration as a model to identify molecular mechanisms involved in cellular reprogramming

2016

more information on Role of Purinergic signaling in human cortical development. A cerebral organoid-based approach

2016

more information on New food-derived bioactive products against obesity and diabetes

2016

more information on Advanced photo systems with biocidal properties for coatings development with application in food and hospital safety

2016

more information on Using animal models for testing interventions targeting malnutrition and stunting in children

2016

more information on Development of Lab-on-a-chip nanostructured sensors for the detection of pathogens and food-borne chemical agents based on Surface-Enhanced Raman Spectroscopy (SERS)

2016

more information on Novel insights, tools and measures to mitigate emerging risk by yeasts in the food chain

2016

more information on Towards a new paradigm in the identification of hazards and evaluation of the safety and risk of neurotoxicity associated to the exposure to nanomaterials with biotechnological applications

2016

more information on Latent heat thermal energy storage by urea-based eutectic mixtures

2016

more information on Heterogeneous biomimetic catalysts based on functionalized organic-inorganic hybrid networks to produce hydrogen

2016

more information on Sunlight on nanocatalysts to lower global energy use, emissions and pollution

2016

more information on Efficient materials for the capture and selective transformation of CO2 towards value-added chemicals

2016

more information on Metal-organic frameworks as heterogeneous photocatalysts for CO2 reduction and H2 generation using H2O

2016

more information on Development of Mimics of Hidrogenases Modulated by Transition Metal Complexes to Produce Hydrogen in the Absence of Molecular Reducing Agents

2016

more information on Photoproduction of hydrogen with atomic quantum clusters using visible light

2016

more information on Graphene: macrophage biomaterials: functional characterization for the use in cardiovascular pathologies

2016

more information on Controlling the magnetism and electronic transport of graphene samples at the atomic scale

2016

more information on Graphene-based flexible neural interfaces for the peripheral nervous system

2014

more information on Tracing tissue damage and the adaptive response in rare hereditary haemochromatosis for the identification of specific therapeutic targets

2014

more information on Cellular response to blocked breakages of DNA and its role in the pathogenesis of Ataxia-Telangiectasia

2014

more information on Characterisation of MORC2, a new gene involved in peripheral neuropathies

2014

more information on Molecular therapy for Laminopathies

2014

more information on New mechanisms for regulating the immune response for lamin A/C and progerine: implications in Hutchinson-Gilford premature ageing síndrome

2014

more information on Models for congenital muscular dystrophies: the search for phenotype suppressors

2014

more information on Identification of the function of the Wt1gene in Huntington's disease

2014

more information on Propionic acidemia: a study which has the aim of optimising its nutritional treatment, metabolic control and quality of life

2014

more information on Study of the molecular bases of hereditary blindness

2014

more information on Agenesis of the corpus callosum. Basic mechanisms and treatment

2014

more information on Precision medicine in Primary Immunodeficiencies: deciphering new genetic etiologies by means of "omic" approaches

2014

more information on The nuclear lamin in Huntington's disease: its role in the pathology and therapeutic applications

2014

more information on Genome and transcriptome analysis to identify splicing defects and in vivo evaluation of antisense therapy

2014

more information on Molecular mechanisms in Dravet's syndrome

2014

more information on Study of intracellular biogenesis and tissue bio-distribution of exosomes for the development of new therapeutic agents

2014

more information on Exosomes: new intercellular communicators and their use as therapeutic agents in untreated parasitic diseases

2014

more information on Exosome optimisation for therapeutic use. The role of tetraspan in-rich micro domains in the biogenesis and function of exosomes

2014

more information on The structural bases of tumoral development associated with transcription regulating interactome defects

2014

more information on Photoselective inhibition of protein-protein interactions to study interactomic networks and the development of new therapies

2014

more information on Study of the tissue-specific interactome of the GRK2 node involved in insulin resistance and obesity: pathological repercussions

2014

more information on New functional complexes deriving from the interaction of Gaq with proteins that contain PB1 domains, and the possible repercussion of this in cardiovascular pathologies

2014

more information on The molecular bases of disease: biointeractomics of programmed cell death

2014

more information on Advanced proteomics and systems biology to study a food allergy

2014

more information on The detection and elimination of biogenic amines in foods: the design of new biosensors and new amino oxidase catalysts

2014

more information on The elimination of endocrine disruptors to improve food security

2014

more information on The development of biotechnological processes for the production of "building blocks" and high added-value glycopolymers with biomedical applications

2014

more information on The development of economically viable protein based biomimetic templates for use in bone tissue regeneration

2014

more information on Methodological advances for obtaining natural biocides to be employed in the food chain based on Mentha spicata extracts

2014

more information on New photocatalysts based on halogenated hybrid perovskites to obtain solar fuels using CO2

2014

more information on The efficient production of solar fuels by means of developing new perovskites with redox capacity for the thermochemical splitting of CO2 and H2O

2014

more information on Metal-free redox flow batteries for the storage of renewable energies. (BAT-LIMET)

2014

more information on "One-pot" catalysed processes for obtaining fuel and chemical products from furfural derivates sourced in biomass

2014

more information on Superconductor materials at (very) high critical temperature

2014

more information on High temperature superconductivity in iron materials

2014

more information on The oncogenic function of IF1: the inhibitor of mitochondrial H+-ATP syntase

2014

more information on Pharmaco-mimetic analysis of the therapeutic value of Vav-dependent metabolic routes in breast cancer

2014

more information on The antitumor effect of GCN2 kinase: the relationship between nutritional stress, protein synthesis and skin cancer

2014

more information on Oxidise NADPH and the regulation of intermediate leukemic cell metabolism: the search for new therapeutic strategies

2014

more information on Inhibition of the protein that regulates SLC4A2 cell ion metabolism as a new therapy in leukaemia, lymphoma and myeloma

2014

more information on Studies of tumorigenesis in Drosophila: possible clinical implications

2014

more information on The diagnosis of cancer by means of a metabolic nanosensor platform

2014

more information on The inhibition of fatty acid syntase lipogenic enzyme (FASN) as a new therapeutic strategy for the treatment of triple negative breast cancer

2014

more information on The AMPK enzyme, a nexus joined metabolism and cancer. A new therapeutic strategy in cerebral glyoblastomas

2014

more information on The effect of antitumour penetrating peptides based on connexin-43 in the selective metabolic reprogramming of human glyoma stem cells

2014

more information on Molecular characterisation of the role of mitochondrial dysfunction in tumoral development

2011

more information on Epigenetic study in vivo of the role of retinoic acid in the regeneration of ciliate cells

2011

more information on Cellular therapy for West's syndrome

2011

more information on Chicken embryonic stem cells. Study of the differentiation between somatic and germinal lineages and between mesodermic and endodermic lineages

2011

more information on Study of the neuroprotector capacity of the epithelial cells of the choroid plexi as a potential regenerative therapy for Alzheimer's disease

2011

more information on The generation of iPSC cells for the study of neurodevelopmental diseases: autism and William's syndrome

2011

more information on Nanotechnologically reprogrammed cellular medicines

2011

more information on In vivo nuclear reprogramming and the functional interrelationship between p27 and SOX2

2011

more information on Myosin II integrates the mechanical signals of the cellular micro-environment and controls the migration and differentiation of stem cells

2011

more information on The subarachnoid administration of previously cryopreserved allogenic stromal cells in traumatic spinal lesion

2011

more information on The complete sequencing of the exomic genome of systemic lupus erythematosus in families of European origin with multiple cases: the identification of rare mutations and their functional consequences

2011

more information on The identification of new genes responsible for Hereditary Dystrophies of the Retina using Next-Generation Sequencing technology and the determination of associated pathogenic mechanisms

2011

more information on Chronic activation of the TGF‑beta route in Marfan's syndrome: deregulation of intracellular traffic and the extracellular matrix

2011

more information on The transplant of bioengineered skin for cutaneous regeneration in patients with Dystrophic Epidermolysis Bullosa

2011

more information on The correction of fibroblasts with mutations causing Wiskott Aldrich syndrome by means of adeno-associated viruses (AAV). The effects of corrective methods on cellular reprogramming by means of episomal vectors

2011

more information on The identification of genetic factors predicting for clonal progression in Systemic Mastocytosis

2011

more information on Modification of the folding and function of mutated opsins by cellular factors as a new therapeutic strategy for degenerative diseases of the retina

2011

more information on Cdk5: a therapeutic target for the treatment of motor and cognitive deficits in Huntington's disease

2011

more information on Modulation of the pathological accumulation of glycogen: therapeutic target for the treatment of Glycogenosis

2011

more information on Directed neuronal differentiation of stem-like glioma initiating cells

2011

more information on Analysis of the contribution of CRB2 protein to the establishment and permanence of adherent joins in the pigmentary epithelium, and its relationship with retinal dystrophies

2011

more information on Molecular mechanisms, experimental models and therapeutic approaches in Frontotemporal Lobe Dementia (DLFT-TDP)

2011

more information on The development of molecular scalpels for the repair of genes involved in single gene diseases

2011

more information on Dominant autosomal sensorineural hypoacusis: expansion of molecular diagnosis by applying new technologies, undertaking functional analysis and creating murine models

2011

more information on Allan-Herndon-Dudley syndrome: molecular mechanisms and a therapeutic approach in the murine model of the disease

2011

more information on Pathological mechanisms in Lysinuria with protein intolerance

2011

more information on Study of the functional implications of GRK2 serine-threonine kinase in Hereditary Haemorrhagic Telangiectasia

2011

more information on Hereditary metabolic diseases: searching for new genes that cause diseases and research into new therapeutic strategies

2011

more information on Translational Research into rare diseases of iron metabolism using massive parallel sequencing

2011

more information on Study of the role of PSGL-1 in the control of the development of autoimmune diseases

2011

more information on Clinical and molecular genetics study of recessive autosomal congenital icthyosis in Spain

2011

more information on The molecular bases for variability in the presentation and clinical development of Wilson's disease

2011

more information on Study of the methylome/genome relationship and their points in common in systemic autoimmune diseases: SLE, RA and SSc

2011

more information on Nutri-epigenetics of the control of body adiposity: studies in animal models of differing susceptibility to obesity based on nutritional interventions in early stages in life

2011

more information on Epigenome and transcriptome of nociception (Functional epigenomics of nociception)

2011

more information on The acetylomes of neural differentiation

2011

more information on Epigenetic alterations in tetraploid neurones and Alzheimer's disease

2011

more information on Experimental study of the epigenetic implications of changes in the composition of fatty acids in the diet during pregnancy and their consequences for adult offspring

2011

more information on The epigenetic regulation of reelin in Alzheimer's disease

2011

more information on The intracellular administration of drugs controlled by biomimetic nano-injectors

2011

more information on The development of biomimetic affinity sensors, based on the molecular printing of polymers prepared by electrodeposition. Application to the detection of metabolites

2011

more information on The biomimetic sealing of dental implants (BIOSELLADO)

2011

more information on Study of the invasion and intracellular traffic of photobacterium damselae subs. piscicida with non-immune cells of the gilthead (sparus aurata)

2011

more information on Reconstruction of the velocity field of ocean currents at a global scale based on satellite observations in the microwave spectrum

2011

more information on The isolation and characterisation of marine bacteria with quorum-quenching activity for the treatment of infectious bacterial diseases

2011

more information on The influence of the structure of combustion aerosols on climate change (AEROCLIMA)

2011

more information on The development of a new generation of nanostructures for the elimination of greenhouse gases (NANO-GEI)

2011

more information on The influence of climate change on the emergence of antibiotic resistance in bacteria

2011

more information on Molecular strategies for the biorepair of mining soils and the maintenance of the balance of atmospheric CO2

2008

more information on Azotobacter vinelandii as bio-factories for producing hydrogen

2008

more information on Using genetic engineering to obtain strains of Clostridium cellulolyticum and Rhodobacter capsulatus that overproduce hydrogen

2008

more information on New therapeutic targets for myotonic dystrophy: analysis of microRNAs in two animal models of the disease

2008

more information on Molecular genetic study of recessive hereditary autosomal hearing loss, linked to X chromosome and maternal mitochondria

2008

more information on Study of the possible immunomodulation caused by Anisakis simplex larval antigens

2008

more information on Type Gaucher's Disease. Phenotypic variability of bone disorders and their study using techniques of genomics, transcriptomics and proteomics

2008

more information on Molecular and cellular bases of mental retardation associated with "Fragile X" syndrome

2008

more information on Testing xenoexpression as gene therapy for mitochondrial diseases

2008

more information on Alternative therapies for inherited metabolic diseases

2008

more information on Towards a complete model of the molecular network disrupted in Fanconi anaemia

2008

more information on Involvement of Ras oncogenes in the development of Costello and Noonan syndromes

2008

more information on Analysis using genetically modified mice of the possible role of alpha-synuclein in the pathogenesis of Huntington's disease

2008

more information on Structural approach to the molecular basis of two rare kidney diseases

2008

more information on Genetic and cellular basis of 16p11.2-p12.2 microdeletion syndrome and related neural disorders

2008

more information on Molecular basis of congenital erythropoietic porphyria. In vivo stability studies of uroporphyrinogen III synthase

2008

more information on Development of a vaccine against Fasciola hepatica based on the use of bioinformatics tools

2008

more information on Sp2-iminosugars as chemical chaperones: a general strategy for the treatment of lysosomal storage disorders

2008

more information on Development of a therapy for the treatment of congenital dyskeratosis, X-linked Werner syndrome and aplastic anaemia based on the reactivation of telomerase activity by an internal fragment of dyskerin

2008

more information on Contributions of aquaporins and transduction proteins in the treatment of achondroplasia

2008

more information on Characterisation of the autoantigen epitope in Goodpasture syndrome using phage display technology

2008

more information on Effect of the oleic acid neurotrophic factor in an animal model of Down syndrome. Implications for central nervous system development

2008

more information on Transcription factors and heterochromatin formation in Drosophila

2008

more information on Role of epigenetic mechanisms in the processes of learning and memory

2008

more information on Association between non-coding RNAs in ultra-conserved regions (T-UCR) and the epigenome: involvement in cancer

2008

more information on Search and identification of new genetic and epigenetic causes of autistic spectrum disorders: design and implementation of a targeted high-resolution array with key elements of the epigenetic machinery

2008

more information on Epigenetic control of cell differentiation and pluripotency by BRAF35 AND iBRAF proteins

2008

more information on Epigenetic regulation of the maintenance of genomic stability during mitotic and meiotic cell cycle

2008

more information on Epigenetic regulation mediated by Ring1A/Ring1B, the ubiquitin ligases of the Polycomb system

2008

more information on Phototherapy: resonant gold nanoparticles in the near infrared for photothermal ablation of tumour cells and for activation of therapeutic genes

2008

more information on Design of new dosage forms for oral administration of immunotherapy for the treatment of food allergy to peanuts

2008

more information on Application of biomaterials with angiogenic, antioxidant and regenerative purposes in the central nervous system

2008

more information on New multifunctional nanostructured materials for biomedical applications

2008

more information on Production of recombinant gonadotropins in Senegalese sole: applications for monitoring and control of sexual maturation in aquaculture

2008

more information on Application of genetic analyses for the creation of germplasm banks in teleostei

2008

more information on Use of nanospheres as a vehicle for the administration of immunostimulants in species of interest to aquaculture (NANOAQUA)

2008

more information on Improvement of the production of fruits and tubers by manipulation of branching patterns in Solanaceae

2008

more information on Biotechnological basis for the development of functional foods in the field of intestinal maturation, inflammatory bowel disease and irritable bowel syndrome

2008

more information on High resolution profiles of acetylation and methylation of histones in the epigenome of Arabidopsis thaliana: functional connection with the biological clock

2008

more information on H2 production from glycerol with the aid of microbial cells isolated from the extremophile ecosystem of Rio Tinto

2008

more information on Study of the regulation of protein PSTPIP1 via tyrosine phosphorylation and its contribution to the aetiology of the PAPA autoinflammatory disease

2008

more information on Detection of molecules related to the mechanism of protection against canine Leishmaniasis. Differential gene expression in cells activated during the protection response induced by the LACK vaccine

2006

more information on Therapeutic trials in cells from patients suffering hereditary haemorrhagic telangiectasis (HHT) and cell gene therapy employing endothelial progenitor cells in an HHT murine model

2006

more information on Characterisation of the astrocytic function in megalencephalic leukoencephalopathy

2006

more information on Neurobiological foundations of and genetic susceptibility to fibromyalgia

2006

more information on Integration and modelling of the metabolism and biological effects of the biogenic amines, biomolecules directly involved in rare and emerging diseases

2006

more information on Characterisation and study of the implications of copy number variations in patients with X chromosome-related mental retardation

2006

more information on Dendritic alterations in Down's Syndrome: the role of the pathway regulating local mTOR translation

2006

more information on Molecular foundations of the human ectodermic dysplasia syndrome

2006

more information on Study of the role of the epigenetic mechanisms in the Fanconi Anaemia cancer tendency phenotype

2006

more information on Molecular analysis of the Ellis-van Creveld Syndrome in the EVC3 epiphyseal growth plate and evaluation of the BBS-EvC connection

2006

more information on Study of the molecular foundations of congenital malformations: cardiovascular, oculofacial and skeletal

2006

more information on Synaptogenesis induced by PI3K in memory processes

2006

more information on Alterations of the CREB-dependent genic expression and its consequences in neurodegenerative and cognitive processes: development of new treatments for Huntington's Disease and Rubinstein-Taybi Syndrome

2006

more information on Molecular foundations of the functional role of isoforms by post-transcriptional alternative splicing processing and with neurotrophin 3 receptor insertion (TrkC) in the memory and learning processes dependent on the cortical-hippocampus circuit

2006

more information on Functional characterisation of the eIF2alpha, GCN2 and PERK kinases in the molecular memory mechanisms

2006

more information on Photoproduction of bioethanol from CO2 using cyanobacteria

2006

more information on Characterisation of plants' resistance mechanisms against heavy metals

2006

more information on Application of alfalfa in phytoextraction of cadmium from contaminated soil

2006

more information on Mechanisms of resistance to heavy metals in significant species in the Riotinto mining basin

2006

more information on Clinical application of pharmacogenetic markers in the treatment of colorectal cancer. Establishment of therapeutic guidelines and recommendations

2006

more information on Search for differential genetic markers between two different types of response to the same allergenic exposure: tolerance versus sensitisation

2006

more information on Transportome as a predictive response element: the importance of nucleoside transporters

2006

more information on Genomic research in patients with an initial schizophrenic episode: identification of genetic and pharmacogenetic markers

2006

more information on Clinical genetic studies of a cohort with hereditary Alzheimer's disease (new locus)

2006

more information on Pharmacogenetics in colorectal cancer

2006

more information on Geno-tPA: Search for predictive genetic patterns for the progress of patients with ischemic ictus following treatment with t-PA

2006

more information on Implications of mevalonic acid, Wnt and oestrogen pathways in osteoporosis and response to antiresorptive drugs

2006

more information on Taxane pharmacogenetics: neurotoxicity and therapeutic efficacy

2006

more information on Study of the impact of genetic polymorphisms in the toxicity of the antiretroviral drugs used to treat HIV

2006

more information on Intestinal inflammatory diseases: susceptibility and pharmacogenetic markers

2006

more information on New cellular and molecular mechanisms for regulating the atheroprotective protein p27 and possible diagnosis applications

2006

more information on Immunity and atherosclerosis. New connections between the lipidic metabolism and microbial infections

2006

more information on Relationship between sensitivity to insulin and the risk of atherosclerotic vascular disease: the European RISC Project

2006

more information on New molecular markers for the formation and development of atherosclerotic plaques: Matrix metalloproteases (MT1-MMP and MT4-MMP) and regulating molecules (EMMPRIN)

2006

more information on Implication of the bioactive sphingolipids in atherogenesis. Biophysical and cellular studies

2006

more information on Influence of genetic and pharmacological factors on innate immunity and immune response in the development of post-transplant arteriosclerosis

2006

more information on Role of chemokines in differentiating monocytes from macrophage/spongy cells and reverse transendothelial migration, in the early stages of arteriosclerosis

2006

more information on Study of the biological role of the new atherosclerosis markers identified by proteomic analysis

more information on Cell-type epigenetic approach to ameliorate Alzheimer's disease: a role for histone methylation

more information on Avances para el diagnóstico precoz de las formas persistentes pre y post tratamiento en la infección crónica con T. cruzi.

more information on Development of an early detection tool for infections based on nano-biotechnology

more information on Comprehensive identification of position-specific mutant p53 protein-protein interactions and their implications for cancer