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Research centres : Instituto de Neurociencias. CSIC-Universidad Miguel Hernández. Alicante.

Javier Sáez Valero

Dr. Sáez Valero graduated in Biology from the University of Murcia, and he received his PhD from the same university in 1996. In the same year of 1996 and by means of a grant from the Ramón Areces Foundation, he started a Postdoctoral stay of two and a half years in the Pathology Dept. of the University of Melbourne, where he studied several interactions between β-amyloid and acetylcholinesterase enzyme, with implications that run from therapy to diagnosis.

He returned to Europe in 2009, where in postdoctoral studies at the Mario Negri Institute, Milan, he researched toxicity and death due to apoptosis of β-amyloid and the prion peptide. Since 2001, he has directed his research group in the Neuroscience Institute of the Miguel Hernández University, of which he is tenured professor. In 2006 he joined CIBERNED, a recently created online research institute which has the aim of bringing together basic and clinical research groups with an interest in neurodegenerative diseases such as Alzheimer's.

Dr. Sáez Valero has dedicated his research work to the investigation of pathologies of the nervous system, with works on cerebral ischaemia, prion disease and hepatic encephalopathy, but above all Alzheimer's, with more than 40 papers published in this field. He is currently trying to advance knowledge about the relationship between abnormal amyloid metabolism and cholinergic regulation; as well as the interrelationship between the amyloid itself and the other event which triggers Alzheimer's disease, the anomalous phosphorylation of tau, together with the role of reelin glycoprotein in the said interrelationship. He also has a line of research into diagnostic markers of Alzheimer's disease. In 2005, he received the "Idea" Prize for Basic Science from the City of Arts and Sciences Foundation for his project in the area of Alzheimer's disease.

Scientific production

  • Article published in Journals: 2
  • Communications in international congresses: 5

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