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Changing the tumor microenvironment: New strategies for immunotherapy

Life and Matter Sciences International Symposium March 21-22, 2012 Pamplona

General information

Venue: Centro de Investigación Médica Aplicada (CIMA) Avda. Pío XII, 55. 31008 Pamplona

  • All sessions will take place in English

Organized by:

Fundación Ramón Areces

Coordinator/s:

Ignacio Melero Centro de Investigación Médica Aplicada (CIMA), Clínica Universidad de Navarra. Universidad de Navarra. Pamplona. Spain

 

Pedro Berraondo CIMA, Clínica Universidad de Navarra. Universidad de Navarra. Pamplona. Spain

 

Viktor Umansky Cancer Research Center (DKFZ), Heidelberg, Alemania. Mannheim University Hospital. Mannheim. Germany

  • Description
  • Programme

The Centre for Applied Medical Research (CIMA) of the University of Navarra in collaboration with the Ramón Areces Foundation has organized in the past three international meetings covering several aspects of immunotherapy which were considered as a great success in the scientific community. This field of knowledge is becoming more and more important as basic research is translated into clinical practice. With the aim to reinforce the scientific heritage lead for the previous meetings, a new meeting will be held. The subject on this occasion is "Changing the tumor microenvironment: New strategies for immunotherapy". Solid tumors are composed of malignant cells surrounded by a tumor-conditioned stroma that contains extracellular matrix and a variety of non-neoplastic populations including myeloid cells, lymphocytes, fibroblasts and endothelial cells. It is thought that the failure to mount an efficient immune response is due to a hostile tumor microenvironment dominated by immunosuppressive cells. The role of regulatory T cells (Treg) and myeloid derived suppressor cells (MDSC) in tumor evasion of immune surveillance has recently been highlighted. Treg and MDSC integrate a common immunoregulatory network within the tumor microenvironment, where tumor-associated macrophages and tumor-associated dendritic cells can also enter into the play. This immunoregulatory network must be overcome in order to achieve eradication of established tumors by immunotherapy. Therefore, the proposed subject is critical for the translation of tumor immunotherapy strategies into clinical practice. The knowledge about the molecules that create the immune-hostile tumor microenvironment is becoming more precise and provides excellent targets for therapeutic intervention.

Two scientists from CIMA and Clínica Universidad de Navarra and a foreign scientist will organize the meeting. From CIMA, Dr. Ignacio Melero, organizer of the previous meetings and Dr. Pedro Berraondo. The foreign organizer will be Dr. Viktor Umansky from the Skin Cancer Unit of German Cancer Research Center (DKFZ, Heidelberg) and University Hospital Mannheim (Germany). A clear translational research orientation will be stressed.

Wednesday, 21

8:30

Presentation

Raimundo Pérez-Hernández y Torra
Director. Fundación Ramón Areces. Spain.

Ignacio Melero 
Symposium Coordinator.

Chairman:
Juan José Lasarte 
Centro de Investigación Médica Aplicada (CIMA). Pamplona. Spain.

9:00

The immune microenvironment of human tumors

Wolf Hervé Fridman
Cordeliers Research Centre. Paris. France.

9:40

Myeloid-derived suppressor cells in tumor microenvironment. Possible target for therapeutic intervention

Dmitry Gabrilovich 
H. Lee Moffitt Cancer Center and Research Institute. University of South Florida. Tampa. United States.

10:20

Hypoxia, CD137, tumor infiltrating lymphocytes and endothelium

Ignacio Melero

11:00

Break

Chairman:
Juan Ruiz 
Digna Biotech. Madrid. Spain.

11:20

Overcoming immunosuppression induced by chronic inflammation in melanoma microenvironment

Viktor Umansky 
Symposium Coordinator.

12:00

Development of immunotherapy strategies aimed at blocking the immunosuppressor tumor microenvironment and enhancing antitumor immune responses

Pedro Berraondo
Symposium Coordinator.

12:40

Immunity and inflammation in the microenvironment of primary melanomas: using the Hgf-Cdk4 mouse model

Thomas Tuting 
Department of Dermatology. University of Bonn. Germany.

13:20

Role of cancer metabolism in adaptive and innate immunity

Licia Rivoltini 
Unit of Immunotherapy of Human Tumors. National Institute of Tumors. Milano. Italy.

14:00

Break

Chairwoman:
Sandra Hervás-Stubbs 
Centro de Investigación Médica Aplicada (CIMA). Pamplona. Spain.

16:00

Chemokines and the microenvironment in human melanoma

Paloma Sánchez Mateos 
Hospital General Universitario Gregorio Marañón. Madrid. Spain.

16:40

Integrin dependent dendritic cell interaction with lymphatic endothelium under inflammatory conditions

Ana Rouzaut  
Centro de Investigación Médica Aplicada (CIMA). Pamplona. Spain.

17:20

CCR5 in cancer immunotherapy: More than an "attractive" receptor for T cells

Santos Mañes  
Centro Nacional de Biotecnología. Madrid. Spain.

18:00

Role of MHC class I altered expression in cancer progression and resistance to immunotherapy

Teresa Cabrera 
Universidad de Granada. Spain.

Thursday, 22

Chairwoman:
Ana Rouzaut

8:30

Cooperation between interleukin-12 and oxaliplatin for the establishment of an efficient immune response against colon cancer

Rubén Hernández  
Centro de Investigación Médica Aplicada (CIMA). Pamplona. Spain.

9:10

Conditioning tumor environment to facilitate CD8+ T cell entry and function

Pawel Kalinski   
University of Pittsburgh and the University of Pittsburgh Cancer Institute. Pittsburgh. United States. 

9:50

Studying T cell-endothelial interactions to improve the immunotherapy toolbox

George Coukos  
Ovarian Cancer Research Center. University of Pennsylvania. Philadelphia. United States.

10:30

Cancer macroenvironment and immmune evasion

Vincenzo Bronte  
Venetian Institute of Molecular Medicine. Padova. Italy.

11:10

Break

Chairman:
Viktor Umansky  

11:30

Building on the success of CTLA-4 blockade using combination strategies and other immune modulators

Jedd Wolchok  
Memorial Sloan-Kettering Cancer Center. New York. United States.

12:10

Targeting regulatory dendritic cells in the tumor microenvironment

Michael Shurin 
Department of Pathology. University of Pittsburgh Medical Center. Pittsburgh. United States.

12:50

Gene profiling of the tumor microenvironment

Ena Wang 
National Institutes of Health. Bethesda. United States.

13:30

Final remarks and meeting adjourn

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