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Joachim Frank

Single-particle cryo-electron microscopy: the visualization of biological molecules in their native states

Life and Matter Sciences Conference Wednesday, June, 12, 2019 19:30h Madrid

General information:

Venue: Fundación Ramón Areces. Vitruvio, 5. 28006. Madrid.

Free admission. Necessary previous online registration. Limited capacity. Simultaneous interpretation.

In cooperation with:

Universidad Autónoma de Madrid

  • Description
  • Programme

For decades, X-ray crystallography has been the only biophysical technique of visualization for biological macromolecules.  Molecules are tightly packed in a crystal and are not necessarily in a structural conformation that corresponds to one of their native, functional states.  Single-particle cryo-electron microscopy (cryo-EM) has solved this problem, as a result of a confluence of advances and inventions in the areas of sample preparation, instrument design, and algorithm design/computation.  In this new era of structural biology, many more biological macromolecules can be visualized, and their structure solved at near-atomic resolution, and these structures represent the molecules in their true native states.

 

Wednesday, June, 12th

19:00 h.

Attendee check-in

19:30 h.

Welcome

Raimundo Pérez-Hernández y Torra 
Director Fundación Ramón Areces.

 

Single-particle cryo-electron microscopy: the visualization of biological molecules in their native states

Joachim Frank 
Nobel Prize in Chemistry, 2017.  Columbia University, New York.

Joachim Frank is a Professor of the Department of Biochemistry and Molecular Biophysics, and a Professor of the Department of Biological Sciences at Columbia University. He received his Ph.D. from the Technical University in Munich and, in 1975, joined the Wadsworth Center in Albany as a Senior Research Scientist. In 1985, he joined the faculty of the Department of Biomedical Sciences in the newly founded School of Public Health of SUNY Albany.  In 2008 he moved to New York to assume his current positions.  Dr. Frank’s lab has developed techniques of electron microscopy and single-particle reconstruction of biological macromolecules, specializing in mathematical and computational approaches.  He has applied these techniques of visualization to explore the structure and dynamics of the ribosome during the process of protein synthesis.

Dr. Frank is a member of the National Academy of Sciences and of the American Academy of Microbiology.  He is also a fellow of the American Academy of Arts and Sciences and of the American Association for the Advancement of Science.  He was recently honored for his contributions to the development of cryogenic electron microscopy of biological molecules and the study of protein synthesis with the 2014 Franklin Medal for Life Science.  In 2017 he shared the Wiley Prize in Biomedical Sciences with Richard Henderson and Marin van Heel.  He was awarded the 2017 Nobel Prize in Chemistry together with Richard Henderson and Jacques Dubochet.

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