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Yeasts: at the cross-roads of Systems biology and Biomedicine. In memory of Professor Julio Rodríguez Villanueva

Life and Matter Sciences International Symposium Thursday and Friday, 23 and 24 January 2020, 9:30 hours Madrid

General information:

Venue: Fundación Ramón Areces. Calle Vitruvio, 5. 28006. Madrid. 

Free admission. Necessary previous online registration. Limited capacity. 
Simultaneous interpretation only in the third session of Friday, 24 (Spanish-English).

Organized by:

Fundación Ramón Areces

Coordinator/s:

Carlos Gancedo Instituto de Investigaciones Biomédicas “Alberto Sols”. Consejo Superior de Investigaciones Científicas - Universidad Autónoma de Madrid. 

César Nombela Departamento de Microbiología, Facultad de Farmacia. Universidad Complutense de Madrid.

  • Description
  • Programme

Yeasts have accompanied mankind since remote times, producing such important goods as bread, wine or beer, without being noticed as the agent of these productions. The great debate on the nature of fermentations in the XIX century made yeast unexpectedly a protagonist in a number of laboratories of the fledging biochemistry. The use of yeast as model organism and testbed has been steady and the complete sequencing of its genome, the first one of an eukaryotic organism, increased even more its value. 

Basic studies using yeasts in such different fields as the regulation of the cell cycle, membrane assembly, protein secretion or vesicular transport have provided knowledge currently used both in fundamental research and in medical practice. The fact that in this century several Nobel Prizes have been awarded to researchers using yeast as their working system is another testimony to the scientific value of these organisms. 

The Symposium “Yeasts: at the cross-roads of Systems biology and Biomedicine” aims to offer a panoramic vision of the growing breadth of yeast research, particularly its continued expansion as a model system in different areas of the life sciences. Systems biology, using the advantages of current technologies, has expanded previous research that tried to understand the physiology of organisms using a reductionist approach. It should not be forgotten, however, that this approach was necessary to attain the current knowledge and is still appropriate in many fields. The use of yeasts as tools to study problems in Biomedicine is clearly illustrated in this Symposium.

We present this Symposium also as a homage to the memory of Professor Julio Rodríguez Villanueva (1928-2017), an extraordinary personality who stimulated the development of microbiology in Spain and who used widely yeasts as a material of study and an experimental system. Several symposia on yeasts sponsored in the past by the Fundación Ramón Areces have a debt of gratitude to his enthusiastic support. Besides his achievements in research, his services to the scientific community in different places -university, scientific societies and committees- make him a prominent figure among the founders of modern Biology in Spain. The last session of the Symposium will be dedicated to evoke different aspects of his work and impact. 

The generosity of the Fundación Ramón Areces has allowed, again, to assemble an international group of productive scientists who use yeasts as an experimental organism in different research areas. The organizers thank this help made explicit from the very initial steps of the application for support. The enthusiastic responses of the speakers that have made possible a symposium of high scientific level are also gratefully acknowledged. 

The organizers believe that a solid basic science is at the roots of innovation, and that the great emphasis demanding immediate translational results, observed with increasing frequency, may slow down the generation of important knowledge, necessary to tackle the acute problems faced by our societies. We hope that the Symposium will attract an important number of interested scientists, using yeasts as biological material, and will highlight the great value of basic research.

Thursday, 23 January

9:00 h.

Attendees check-in

9:30 h.

Opening session

Federico Mayor Zaragoza 
Presidente del Consejo Científico de la Fundación Ramón Areces, Madrid. Spain.

Carlos Gancedo 
Instituto de Investigaciones Biomédicas “Alberto Sols”. Consejo Superior de Investigaciones Científicas - Universidad Autónoma de Madrid. Spain.

Session 1

Chairman: César Nombela 

 9:45 h.

Writing the yeast genome

Jef D. Boeke
Institute for Systems Genetics. NYU Langone Health, New York. EE.UU.

10:30 h.

Regulation of gene expression in yeast through the CWI pathway  

Javier Arroyo
Departamento de Microbiología y Parasitología, Facultad de Farmacia. Universidad Complutense de Madrid. Spain.

 

11:15 h.

Break 

Session 2

Chairman: Víctor J. Cid 

 11:45 h.

A moonlighting protein in the non-conventional yeast Yarrowia lipolytica

Carmen-Lisset Flores
Instituto de Investigaciones Biomédicas “Alberto Sols”. Consejo Superior de Investigaciones Científicas - Universidad Autónoma de Madrid. Spain.

12:30 h.

Yeast to study the function of the translation factor eIF5A in health and disease

Paula Alepuz  
Departamento de Bioquímica y Biología Molecular, Facultad de Ciencias Biológicas. Universitat de València. Spain.

 

13:15 h.

Break

Session 3

Chairman: Joaquín Ariño 

 15:30 h.

What determines nuclear size? Findings in yeast with cancer implications

Orna Cohen-Fix
Laboratory of Biochemistry and Genetics, NIDDK, NIH, Bethesda. EE.UU.

16:15 h.

The NPC basket, a stress-sensing “hub” for nuclear functions 

Catherine Dargemont
Institute for Human Genetics. Montpellier. France.­­­­­­­

 

17:00 h.

Break 

Session 4

Chairman: Javier Arroyo

 17:30 h.

Candidalysin discovery and function

Julian Richard Naglik
Centre for Host-Microbiome Interactions. King’s College London. United Kingdom.

18:15 h.

The Rts1 regulatory subunit of PP2A is essential for septin organization in Candida albicans

Carlos R. Vázquez de Aldana
Instituto de Biología Funcional y Genómica (IBFG). Consejo Superior de Investigaciones Científicas - Universidad de Salamanca. Spain.

 

Friday, 24 January

9:00 h.

Attendees check-in

Session 1

Chairman: Paula Alepuz

 9:30 h.

Humanized yeast models in Biomedicine: Assembling Signaling Modules in Cancer and Innate Immunity

Víctor J. Cid
Departamento de Microbiología y Parasitología, Facultad de Farmacia. Universidad Complutense de Madrid. Spain.

10:15 h.

Budding yeast as a powerful model to decipher meiotic quality controls preventing reproductive disorders 

Pedro San Segundo 
Instituto de Biología Funcional y Genómica (IBFG). Consejo Superior de Investigaciones Científicas - Universidad de Salamanca. Spain.

 

11:00 h.

Break

Session 2

Chairman: Pedro San Segundo  

 11:30 h.

When protein phosphatases go mad: the molecular bases of the toxicity of fungal phosphatase Ppz1

Joaquín Ariño
Institut de Biotecnologia i de Biomedicina. Departamento de Bioquímica y Biología Molecular, Universitat Autònoma de Barcelona. Spain.

12:15 h.

Yeast-based ethanol production: improving product yield and robustness by metabolic engineering

Jack T. Pronk
Department of Biotechnology, Delft University of Technology. Netherlands.

 

13:00 h.

Break

Session 3

Chairman: Carlos Gancedo

 15:30 h.

Family background and ties with Piloña of Professor Villanueva

Iván Allende Toraño
Alcalde del Ayuntamiento de Piloña, Principado de Asturias. Spain.

15:45 h.

Old remembrances and current appreciation of Don Julio 

Félix M. Goñi 
Presidente de la Sociedad Española de Bioquímica y Biología Molecular (SEBBM). Departamento de Bioquímica y Biología Molecular. Universidad del País Vasco. Spain.

16:00 h.

The contribution of Professor Villanueva to the Spanish Society of Microbiology 

Antonio Ventosa Ucero
Presidente de la Sociedad Española de Microbiología (SEM). Departamento de Microbiología y Parasitología, Facultad de Farmacia. Universidad de Sevilla. Spain.

16:15 h.

Julio R. Villanueva: a scientific school with  a strong influence 

César Nombela
Departamento de Microbiología, Facultad de Farmacia. Universidad Complutense de Madrid. Spain.

16:30 h.

The scientific legacy of Professor Villanueva in Salamanca and its future development 

Sergio Moreno
Instituto de Biología Funcional y Genómica (IBFG). Consejo Superior de Investigaciones Científicas - Universidad de Salamanca. Spain.

16:45 h.

Don Julio: a scientific pioneer and a person committed with university 

José Ramón Alonso Peña
Instituto de Neurociencias de Castilla y León. Universidad de Salamanca. Spain.

17:00 h.

Julio Rodríguez Villanueva, Science and Conscience 

Federico Mayor Zaragoza
Presidente del Consejo Científico de la Fundación Ramón Areces, Madrid. Spain.

17:15 h.

Closing remarks 
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