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Proyectos
Research projects
Investigation on hybrid molecules as powerful novel therapeutic approaches for Multiple Sclerosis and myelin- related rare diseases
19th National Research Competition in Life and Earth Sciences
Amyotrophic Lateral Sclerosis (ALS) and Multiple Sclerosis (MS): Molecular Etiology and Novel Treatments
Senior Researcher : Fernando de Castro Soubriet
Research Centre or Institution : Instituto Cajal. CSIC. Madrid.
Abstract
Together with the group of Dr. Valle Palomo at IMDEA Nanociencia, we have continued our work in the following work pipeline:
A second extended in vivo study of protection in the experimental autoimmune encephalomyelitis model of an LRRK-2 inhibitor molecule has been performed. Objective: To determine whether an LRRK2 inhibitor molecule capable of inducing the proliferation and differentiation of oligodendrocyte precursor cells could recover the symptoms in an in vivo model of multiple sclerosis. Results: It has been observed that the tested molecule is capable of reducing the clinical symptoms in a statistically significant manner in this model and of reducing histological lesions and therefore is a proposed candidate for the treatment of this disease. Next Steps: An article on the results is currently being written for publication with the following title and participating authors:
Scientific Production |
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| Magazine Articles | 1 |
| Communications at national conferences | - |
| Communications at international conferences | 2 |
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Activities related
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Projects related
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News related
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Publications related
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22
Jun
2022
International Symposium Cuidados paliativos globales: retos y expectativas futuras Madrid, Wednesday, 22 June 2022, 16:00 hours
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27
Oct
2022
Scientific Symposium Mecanismos de muerte celular en la ELA: posibilidades para el manejo clínico de la enfermedad. VI Encuentro internacional de la ELA en España Madrid, Thursday, 27 October 2022, 16:00 hours
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4
Oct
2023
Session VII International ALS meeting in Spain: 30 years learning about ALS: new scenarios and challenges Madrid, Wednesday, 4 October 2023, 16:00 hours
- Progression of different forms of multiple sclerosis related to the stem/progenitor cells potential 2018 Senior Researcher : Laura López Mascaraque Research Centre or Institution : Instituto Cajal. CSIC. Madrid.
- Significance of brain glucose hypometabolism and of altered insulin signal transduction in an experimental model of amiotrophic lateral esclerosis (ALE) 2018 Senior Researcher : Enrique Blázquez Fernández Research Centre or Institution : Universidad Complutense de Madrid
- Functional characterization and mechanisms of the signalling kinase MOK in neuroinfiammation associated to Amyotrophic Lateral Sclerosis (ALS) 2018 Senior Researcher : Cintia Roodveldt Research Centre or Institution : Centro Andaluz de Biología Molecular y Medicina Regenerativa (CABIMER)
