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Andrew T. Chan

Diet, the gut microbiome and colorectal cancer

Life and Matter Sciences Conference Monday, June, 17, 2019 19:00 hours Madrid

It is part of the International Seminar of June, 18:
"Gut microbiota and colorectal cancer: risk factors and prevention".

General information:

Venue: Fundación Ramón Areces. Vitruvio, 5. 28006. Madrid.

Free admission. Necessary previous online registration. Limited capacity. Simultaneous interpretation.

Coordinator/s:

Fulgencio Saura Calixto Scientific advisor, Investigation exprofesor of Consejo Superior de Investigaciones Científicas (CSIC), Madrid. 

 

  • Description
  • Programme

Since the gut microbiome was sequenced and published in 2010, intensive biomedical research has highlighted the key role of microbiota in human health. The gut microbiota extends its action from the colon to other organs and tissues, including the brain. The microbiota catabolizes indigestible diet components to produce metabolites that affect gene expression and that may have beneficial or detrimental effects on immune function, intestinal inflammation, metabolic syndrome and neurological functions.This seminar focuses on the mechanisms of action and the effects of the gut microbiota in the prevention of colon cancer, the second cause of cancer death worldwide. Special attention will be paid to the interactions of the microbiota with non-digestible carbohydrates and antioxidants, which are the two main diet components affecting the composition and function of the microbiota, and its potential health effects. The main risk factors in the modulation of intestinal microbiota associated with inappropriate eating habits will also be discussed. The speakers will present their most recent research results on these topics.

 

Monday, June, 17

18:30 h.

Attendee check-in

19:00 h.

Welcome and presentation of the seminar

José María Medina 
Scientific Council Fundación Ramón Areces.

Fulgencio Saura Calixto 
Coordinator of the seminar.

 

Inaugural conference: Diet, the gut microbiome and colorectal cancer

Andrew T. Chan 
Massachusetts General Hospital. Brigham & Women's Hospital.  Harvard TH Chan School of Public Health. Harvard Medical School, Harvard. Boston, EE.UU..

Abstract

Long-term diet is associated with alterations in the gut microbiome and colorectal cancer.  

Recent experimental data demonstrate that the gut microbiome may contribute to colorectal carcinogenesis through modulation of host immunity and activation of pathways associated with cellular proliferation. Prudent dietary patterns – rich in fruits, vegetables, and whole grains – have been associated with a lower risk of colorectal cancer and adenoma. In contrast, Western dietary patterns – dominated by red and processed meats – have been linked with colorectal carcinogenesis. Although mechanisms underlying these diet-cancer associations remain unclear, it is postulated that the gut microbiota, including specific bacteria such as Fusobacterium nucleatum, may play a mediating role, potentially through the production of microbial metabolites such as hydrogen sulfide.

Evidence also suggests that diet influences the composition and function of the gut microbiome and metabolome. In this session, we will discuss work from our group supporting the hypothesis that diet-cancer associations may be mediated by modulation of the gut microbiome.   


Bio

Andrew T. Chan is Research Professsor at the Harvard Medical School and   gastroenterologist at Massachusetts General Hospital and Brigham & Women’s Hospital, Boston, EE.UU..

His work is  currently focused on chronic digestive diseases, including gastrointestinal cancer (colorectal, esophageal, pancreatic), inflammatory bowel disease and  diverticulitis. He also has major effort in investigating the  gut microbiome   to elucidate the underlying mechanisms mediating associations among diet, lifestyle, and tumorigenesis. His research in colorectal cancer prevention utilize molecular approaches encompassing genetic, metabolomic, proteomic, and biochemical platforms applied to populations.

The American Society of Clinical Oncology heralded his early studies  on the reduction in risk of colorectal cancer associated with aspirin as one of the 18 most notable advances in cancer research of 2007.

Andrew T. Chan is one of the most cited biomedical researchers. He has published over 180 articles in leading medical journals in the last five years (JAMA, BMJ, Gut, Lancet, Gastroenterology, Nature, Clinical Cancer Res and others).

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