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Research projects
Epigenetic regulation mediated by Ring1A/Ring1B, the ubiquitin ligases of the Polycomb system
15th National Research Competition in Life and Earth Sciences
The genome and epigenome
Senior Researcher : Miguel Ángel Vidal Caballero
Research Centre or Institution : Centro de Investigaciones Biológicas (CSIC)
Abstract
Polycomb group genes encode proteins that assemble into two main types of complexes characterised by their histone-modifying activity. One of them, through the activity of two protein-ligases, Ring1A and Ring1B, is responsible for the monoubiquitination of histone H2A, often associated with gene repression in a variety of contexts. The project addresses two main objectives. One is to determine whether the different protein complexes containing Ring1A and Ring1B perform separable roles in a model of mouse embryonic stem cells. The other, using a genetic approach that allows controlled inactivation of Ring1A and Ring1B proteins in mice, is to establish common and differential elements in their activities in foetal and adult stages in progenitor cells in neural and haematopoietic systems.
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16
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2023
Conference Nuevas estrategias contra el cáncer: poner el carro delante de los caballos Madrid, Thursday, 16 March 2023, 19:00 hours
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18
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9
May
2024
Conference Genes de mosca y genes humanos: una comparación Madrid, Jueves 09 de mayo de 2024, 19:00 horas
- Development of new targets for immunotherapy in cancer metastasis 2016 Senior Researcher : José Ignacio Casal Álvarez Research Centre or Institution : Centro de Investigaciones Biológicas (CSIC)
- Tumor microbiome and immune profiles as predictors of treatment response in high-risk non-muscle invasive bladder cancer (MIT-BC Study) 2020 Senior Researcher : Nuria Malats Riera y Ravid Straussman Research Centre or Institution : Centro Nacional de Investigaciones Oncológicas. Madrid y el Weizman Institute of Science. Rehovot
- Spanish National Brain Metastasis Network (RENACER): Implementation, Development and Coordination 2020 Senior Researcher : Eva Ortega Paíno Research Centre or Institution : Centro Nacional de Investigaciones Oncológicas (CNIO). Madrid
