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Molecular foundations of the functional role of isoforms by post-transcriptional alternative splicing processing and with neurotrophin 3 receptor insertion (TrkC) in the memory and learning processes dependent on the cortical-hippocampus circuit
14th National Research Competition in Life and Earth Sciences
Molecular memory mechanisms
Senior Researcher : Mara Dierssen Sotos
Research Centre or Institution : Centro de Regulación Genómica. Barcelona
Abstract
Learning is the result of a delicate balance in which several molecular cascades intervene. Neurotrophins and their receptors may act as regulators of learning and memory effectiveness. To date, the role of neurotrophin systems, such as "NT3-TrkC", in the pathological alterations of said processes is unknown. The study will be conducted on transgenic mice with an overexpression of the NT-3 TRkC receptor with the help of molecular techniques, which will enable us to determine the relationship between learning and memory and their molecular and cellular processes.
Through this experimental model, we will attempt to verify whether these animals increase neuron production and survival in the hypocamp (a brain structure related to learning and memory) and its consequences on neuronal plasticity, learning and memory in adult mice.
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12
Jun
2019
Conference Single-particle cryo-electron microscopy: the visualization of biological molecules in their native states Madrid, Wednesday, June, 12, 2019 19:30h
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25
Feb
2020
Conference The Gendered Brain: How our world can change our brains and make up our minds Madrid, Tuesday, 25 February 2020, 19:00 hours
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30
Nov
2021
Conferencia online Misterios de la mente humana: el futuro del cerebro y las ciencias neuronales ONLINE www.fundacionareces.tv/directo, Tuesday, 30 November 2021, 19:00 hours
- Molecular therapy for Laminopathies 2014 Senior Researcher : Ana María González García Research Centre or Institution : Centro Nacional de Biotecnología (CNB). CSIC. Madrid
- Study of the molecular bases of hereditary blindness 2014 Senior Researcher : Ana Méndez Zunzunegui Research Centre or Institution : Instituto de Investigación Biomédica de Bellvitge (IDIBELL). Barcelona.
- Molecular mechanisms in Dravet's syndrome 2014 Senior Researcher : Francisco Zafra Gómez Research Centre or Institution : Centro de Biología Molecular "Severo Ochoa". CSIC-Universidad Autónoma de Madrid
