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Research projects
Structural approach to the molecular basis of two rare kidney diseases
15th National Research Competition in Life and Earth Sciences
Rare diseases
Research Centre or Institution : Centro de Investigaciones Biológicas (CSIC)
Abstract
The complement system plays a critical role in innate immunity and its deregulation leads to serious rare diseases due to a lack of treatments, such as dense deposit disease (DDD) or atypical haemolytic uraemic syndrome (aHUS). This project aims to combine genetic, biochemical and structural studies to resolve the mechanisms regulating complement system activation. Resolved structures will allow the identification of critical regions in the assembly and regulation processes, which will help explain the mutations found in patients as well as facilitate the design of compounds to prevent or reduce tissue damage caused by uncontrolled activation of the complement system.
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30
Jan
2020
International Symposium Understanding and reprogramming developmental visual disorders: from anophthalmia to cortical impairments Madrid, Thursday and Friday, 30 and 31 January 2020, 9:30 hours
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8
Apr
2024
Panel Discussion Mundo de las prótesis, los nuevos materiales, sus complicaciones y su futuro Madrid , Lunes, 8 de abril 2024. 17.00 horas
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23
Apr
2024
Session Situación actual de las Enfermedades Raras en España Madrid, Martes, 23 de abril de 2024, 10:00 horas
- Therapeutic trials in cells from patients suffering hereditary haemorrhagic telangiectasis (HHT) and cell gene therapy employing endothelial progenitor cells in an HHT murine model 2006 Senior Researcher : Luisa María Botella Cubells Research Centre or Institution : Centro de Investigaciones Biológicas (CSIC)
- Detection of molecules related to the mechanism of protection against canine Leishmaniasis. Differential gene expression in cells activated during the protection response induced by the LACK vaccine 2008 Senior Researcher : Vicente Emilio Larraga Rodríguez de Vera Research Centre or Institution : Centro de Investigaciones Biológicas (CSIC)
- Molecular mechanisms, experimental models and therapeutic approaches in Frontotemporal Lobe Dementia (DLFT-TDP) 2011 Senior Researcher : Ángeles Martín Requero Research Centre or Institution : Centro de Investigaciones Biológicas (CSIC)
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La Fundación Ramón Areces refuerza su compromiso con las enfermedades raras
Published on 04/23/2024
