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Genetics & ALS: Implications and challenges in knowledge, diagnosis and disease management

Life and Matter Sciences

Fra Papers 2019

Authors:

Alberto García Redondo
John Landers
Adolfo López de Munain
Ana Cristina Calvo
Caterina Bendotti
Maria Antonia Barceló
Pedro Vizán
Ammar Al-Chalabi
Valentina Gallo
Ernest Milián
Mimoun Azzou
Rosario Osta

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Synopsis

As with other major neurodegenerative diseases such as Alzheimer’s or Parkinson’s disease ,Amyotrophic Lateral Sclerosis (ALS) is a disease that can be hereditary. It is known that 5 to 10% of patients with ALS have or have had fi rst or second-degree family members with the same disease or frontotemporal dementia. It has focused on the genetic implications and the challenges in knowledge, diagnosis and management of the disease.

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